Detailed information of TA system TA191873

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1570428..1571107
• Replicon: chromosome
• Accession: NZ_CP069840
• Organism: Acinetobacter baumannii strain FDAARGOS_1360

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: I6K90_RS07715
• Protein ID: WP_000838146.1
• Coordinates: 1570925..1571107 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: I6K90_RS07710
• Protein ID: WP_000966688.1
• Coordinates: 1570428..1570832 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K90_RS07675	1565721..1566236	-	516	WP_001056868.1	Rha family transcriptional regulator	-
I6K90_RS07680	1566577..1567512	-	936	WP_000254125.1	ORF6N domain-containing protein	-
I6K90_RS07685	1567662..1567928	+	267	WP_000774879.1	hypothetical protein	-
I6K90_RS07690	1567971..1568462	-	492	WP_000755583.1	DUF4468 domain-containing protein	-
I6K90_RS07695	1568548..1569294	-	747	WP_000599537.1	hypothetical protein	-
I6K90_RS07700	1569356..1569739	-	384	WP_000725052.1	hypothetical protein	-
I6K90_RS07705	1569804..1570328	-	525	WP_000721574.1	DUF4468 domain-containing protein	-
I6K90_RS07710	1570428..1570832	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
I6K90_RS07715	1570925..1571107	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
I6K90_RS07720	1571433..1571948	-	516	WP_025464510.1	hypothetical protein	-
I6K90_RS07725	1572019..1572936	-	918	WP_000094247.1	hypothetical protein	-
I6K90_RS07730	1572989..1574344	-	1356	WP_000002417.1	hypothetical protein	-
I6K90_RS07735	1574344..1574697	-	354	WP_000064601.1	hypothetical protein	-
I6K90_RS07740	1574766..1575164	-	399	WP_001251854.1	hypothetical protein	-
I6K90_RS07745	1575166..1575534	-	369	WP_025464509.1	HK97 gp10 family phage protein	-
I6K90_RS07750	1575506..1575910	-	405	WP_000247946.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1551418..1602795	51377

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T191873 WP_000838146.1 NZ_CP069840:c1571107-1570925 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T191873 NZ_CP091977:c2214533-2214267 [Aromatoleum aromaticum]
GTGGTAAGTTGGGAAGTCGTTTATGCCAGGCAAGCATTGAAGGATGCAAAGAAACTTGCTGCAAGCGGTCTTAAACCAAA
GGCGCAAGAACTGCTCGCGGTTCTTGCCGACGACCCATTTAAAAATCCACCTCCCTTTGAAAAATTGGTCGGTGATCTTG
CCGGCGCATACTCTCGTCGCATCAATATTCAACACCGCATCGTGTACGAAGTCTTTGCCAACGAGAAAACGGTTCGCGTC
CTGCGTATGTGGACGCACTATGAATGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT191873 WP_000966688.1 NZ_CP069840:c1570832-1570428 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT191873 NZ_CP091977:c2214769-2214527 [Aromatoleum aromaticum]
ATGAACACACTGACCGCCAGCGAAGCCCGGGCAAATCTTTACCGGCTCATTGATCAAACAGTTGAGTCTCATGAGCCAAT
CATCATTACCGGAAAACGCAACAGTGCCGTGCTTCTCTCCGCAGAAGACTGGAGCGCAATTCAGGAAACTCTGTACCTGC
TAGCCGTACCTGGCATGCGTGAGTCCATCAAGGCGGGCATGGCCGAACCTCTCGCAAAAAGCTCGAAGGAGCTTAAGTGG
TAA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6