Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 27632..28275 Replicon plasmid unnamed2
Accession NZ_CP069829
Organism Klebsiella pneumoniae strain FDAARGOS_1327

Toxin (Protein)


Gene name vagD Uniprot ID Q84A06
Locus tag I6K57_RS26340 Protein ID WP_000754566.1
Coordinates 27859..28275 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag I6K57_RS26335 Protein ID WP_001261276.1
Coordinates 27632..27862 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K57_RS26300 22751..23020 + 270 WP_000339857.1 hypothetical protein -
I6K57_RS26305 23197..24063 - 867 WP_004118283.1 replication initiation protein -
I6K57_RS26310 24593..24697 + 105 WP_032409716.1 hypothetical protein -
I6K57_RS26315 24826..25083 + 258 WP_000764642.1 hypothetical protein -
I6K57_RS26320 25141..25917 - 777 WP_000015958.1 site-specific integrase -
I6K57_RS26325 25914..26657 - 744 WP_000129823.1 hypothetical protein -
I6K57_RS26330 26708..27058 - 351 WP_000493378.1 hypothetical protein -
I6K57_RS26335 27632..27862 + 231 WP_001261276.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
I6K57_RS26340 27859..28275 + 417 WP_000754566.1 type II toxin-antitoxin system VapC family toxin Toxin
I6K57_RS26345 28479..29335 + 857 Protein_30 IS3-like element ISEc15 family transposase -
I6K57_RS26350 29617..30693 + 1077 WP_000227969.1 IS110 family transposase -
I6K57_RS26355 31334..31417 + 84 Protein_32 SOS response-associated peptidase -
I6K57_RS26360 31580..33079 - 1500 Protein_33 Tn3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..39709 39709


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(8-64)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 17834.22 Da        Isoelectric Point: 12.9398

>T191872 WP_000754566.1 NZ_CP069829:27859-28275 [Klebsiella pneumoniae]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 417 bp

>T191872 NZ_CP091977:2210971-2211159 [Aromatoleum aromaticum]
GTGACGGACATCTGGGCAGCGGTCGGCGCAGAAGCGCCCGTCGTCGAGCTCGCAGGCGATCTCGTGCGGCTCGTCGAGAG
CCAGGAGCAGATCGCGACGAACCGCCTCGTCGATACGCTCGAGGAACAGGCGCTTCTCGAATCCCTGCTGGAAACTTCGA
AGCCGCCGCTGCCGCAAGGTAAGCGGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 9887.42 Da        Isoelectric Point: 12.6808

>AT191872 WP_001261276.1 NZ_CP069829:27632-27862 [Klebsiella pneumoniae]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 231 bp

>AT191872 NZ_CP091977:2210615-2210974 [Aromatoleum aromaticum]
ATGAGCGTTGCTGCCCTTCGCAAACCCGATGCGACGCAGGTCGTCACCAAGGCCCTGCTCAACGCCGGCAAGGAAATGGG
ATTGACGCAGGCGGCGCTGGGCGTGGTCATCGGCAAGGACCGCACCGCGATCAGCCGCAACGGCATCGACCCCGACAGCA
AGGCGGGAGAGCTCGCGCTGCTGCTGATCCGCGCGTATCGCGCGCTGTTCGCGCTCGTCGGCGGCGACGCCGCGCAGATG
AAGCACTGGATGCACACCGACAACCACCACGTCGGCGGCGTCCCGGCCGAGCAGATTCGCACCGTCCAGGGTTTGCTGCG
CGTCGTCGAATACCTCGACGCGATCCGCGGCCGGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A387K1G3

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References