Detailed information of TA system TA191852

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 3571617..3573216
• Replicon: chromosome
• Accession: NZ_CP069820
• Organism: Bordetella pertussis strain FDAARGOS_1368

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: Q7VVM6
• Locus tag: I6K98_RS17025
• Protein ID: WP_003816876.1
• Coordinates: 3571876..3573216 (+)
• Length: 447 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: I6K98_RS17020
• Protein ID: WP_019247974.1
• Coordinates: 3571617..3571874 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K98_RS17005	3567280..3567891	-	612	WP_010931041.1	DUF2239 family protein	-
I6K98_RS17010	3568114..3569574	+	1461	WP_003812368.1	IMP dehydrogenase	-
I6K98_RS17015	3569671..3571263	+	1593	WP_010931040.1	glutamine-hydrolyzing GMP synthase	-
I6K98_RS17020	3571617..3571874	+	258	WP_019247974.1	helix-turn-helix domain-containing protein	Antitoxin
I6K98_RS17025	3571876..3573216	+	1341	WP_003816876.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6K98_RS17030	3573312..3574001	-	690	WP_010931038.1	TetR/AcrR family transcriptional regulator	-
I6K98_RS17035	3574014..3575444	+	1431	WP_019247976.1	MFS transporter	-
I6K98_RS17040	3575676..3576754	+	1079	Protein_3354	tellurite resistance/C4-dicarboxylate transporter family protein	-
I6K98_RS17045	3577169..3577990	+	822	WP_014905903.1	IclR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (10-112)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-70)

Sequences

Toxin

Protein

• Length: 447 a.a.
• Molecular weight: 49632.79 Da
• Isoelectric Point: 7.4158

>T191852 WP_003816876.1 NZ_CP069820:3571876-3573216 [Bordetella pertussis]
MGRRSHSRSLSIWTNGVRVGRWTVPARGEMELQYDVDWVRADVGRPLSLSLPFNLQNLPLKGERVANYFDNLLPDSDAIR
RRVAERFRTGSVDPFDLLKAIGRDCVGAVQILEDEEIPEGFDRIEGVPLSEEDIERHLIETVTPRAFAAGRDPDADFRIS
LAGAQEKTAFLWWGGQWLAPRGATSTSHIFKLPLGLVGGRRADFSTSVDNEWLCLKLLKAYGLDVAEASIATFGQQRVLV
VERFDRRVAPNGQWLMRLPQEDFCQVEGCSPLRKYENEGGPGLKALFATLRQSVNAAVDMRTLMAAQILFWLLRAPDGHA
KNFSIQLLPRGRFQLTRLYDVMSAYPVLGDGANQWSPFEIKLAMALIGKNRHYEMHGIQRRHFNSTAQKVGYGPTAEPII
EDLLARTPAIIAAVQADLPQDFSPRVADSVLGGLAQAAKSLGAMMP

Nucleotide

• Length: 1341 bp

>T191852 NZ_CP091966:c18757-18659 [Leptospira noguchii]
GTGTGGCTGAACTTTACTCCTCAAGCAGGTCATGAACAGAAAGGTCGTAGACCTGCACTTGTTTTATCGCCTAAGGAATA
TAATTCAAAGACAGGTTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 8815.04 Da
• Isoelectric Point: 7.1642

>AT191852 WP_019247974.1 NZ_CP069820:3571617-3571874 [Bordetella pertussis]
MPPPSQPLLTTGQLGAVLQAARKAQGLTQSALASRIGLSQSRVSHLELNAHQLSVEQLLAWCAALGLELTIATRGSPAGS
SDADW

Nucleotide

• Length: 258 bp

>AT191852 NZ_CP091966:c19008-18793 [Leptospira noguchii]
ATGGGTAATAGCTTAGGAATTAGAATTCCAAAAGCAATGGCAACGGAATTAGAGTTAAATGATGGAAGCCATGTTGAATT
ACAATATGAAGGAGATAAGATTGTAATATATCCAATGAAAAAAGCTTCATTGGAAGATAAACTTTCTAAAATTACGAAAC
AAAATCTTCACTCTGAAATATCTACTGGTAATTCTATAGGCAATGAAGCTTGGTAA

Structures

Toxin

• AlphaFold DB: Q7VVM6