Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4468099..4468718 Replicon chromosome
Accession NZ_CP069815
Organism Raoultella planticola strain HH15

Toxin (Protein)


Gene name Hha Uniprot ID A0A514EV16
Locus tag G9395_RS21160 Protein ID WP_004858783.1
Coordinates 4468500..4468718 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A514EV88
Locus tag G9395_RS21155 Protein ID WP_004858785.1
Coordinates 4468099..4468473 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9395_RS21145 4463210..4464403 + 1194 WP_032689203.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
G9395_RS21150 4464426..4467572 + 3147 WP_032689204.1 multidrug efflux RND transporter permease subunit -
G9395_RS21155 4468099..4468473 + 375 WP_004858785.1 Hha toxicity modulator TomB Antitoxin
G9395_RS21160 4468500..4468718 + 219 WP_004858783.1 hemolysin expression modulator Hha Toxin
G9395_RS21165 4468870..4469436 + 567 WP_032689205.1 maltose O-acetyltransferase -
G9395_RS21170 4469536..4470006 + 471 WP_094898483.1 YlaC family protein -
G9395_RS21175 4469981..4471432 - 1452 WP_094898484.1 PLP-dependent aminotransferase family protein -
G9395_RS21180 4471535..4472245 + 711 WP_046853014.1 GNAT family N-acetyltransferase -
G9395_RS21185 4472242..4472382 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
G9395_RS21190 4472385..4472645 - 261 WP_032689208.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8570.90 Da        Isoelectric Point: 7.9907

>T191849 WP_004858783.1 NZ_CP069815:4468500-4468718 [Raoultella planticola]
MSGEPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T191849 NZ_CP091962:c745104-744763 [Leptospira noguchii]
ATGATTCGTGGTGAGATCTGGTGGGTGGACTTAGGAATTCCATTTGGAAGTGAACCTGGATTTAAGCGACCCGTTTTGAT
TATTCAAGATGACTCTTTTAATCAAAGTAGTATCAGTACTGTAGTATCGATTGCGATTACATCAAATTTAAATTTGTCTG
AAGCTCCTGGCAATGTTCTGATCAGTAAGAAAGAATCCAGCTTATCAAAAGATTCAGTTGTGAATGTCTCTCAAATCGTG
ACTTTAGATAAAGAGAGATTCATTAAACGGGCGGGAAAGCTTAAATCAAGTAAGATCAACGAAGTTGAAACAGGCCTCAA
GTTAGTTACAGGCTTAAATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14411.19 Da        Isoelectric Point: 4.8989

>AT191849 WP_004858785.1 NZ_CP069815:4468099-4468473 [Raoultella planticola]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYAEDNKLIAQLDEYL
DDTFMLFSSYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT191849 NZ_CP091962:c745339-745091 [Leptospira noguchii]
ATGAAAACTGCGATTTCGATTCCAGATGAGTTATTCAAGACTGCTGAGAAAATAGCAAAAAAACTTGGAATACCTCGAAG
TCAGCTTTTTGCAAAGGCATTAGAAGAATTTATTCAATCCCATAGTAAAGAATCTATAACTGAGAAGTTAAATAAAGTTT
ATAGCAATAAATCCAAAGAGCTTAAAAGTAATATCGTAGATTTATCCGTAGAATCACTGCGTAAGAGTTTAAAAAATGAT
TCGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A514EV16

Antitoxin

Source ID Structure
AlphaFold DB A0A514EV88

References