Detailed information of TA system TA191847

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2885867..2887470
• Replicon: chromosome
• Accession: NZ_CP069815
• Organism: Raoultella planticola strain HH15

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: G9395_RS13735
• Protein ID: WP_046852509.1
• Coordinates: 2885867..2887198 (-)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A2X2EM10
• Locus tag: G9395_RS13740
• Protein ID: WP_032696205.1
• Coordinates: 2887198..2887470 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9395_RS13720	2881743..2882657	-	915	WP_015584333.1	branched-chain amino acid ABC transporter permease	-
G9395_RS13725	2882757..2883815	-	1059	WP_162180097.1	branched-chain amino acid ABC transporter substrate-binding protein	-
G9395_RS13730	2884528..2885934	+	1407	WP_032699891.1	glycoside hydrolase family 10 protein	-
G9395_RS13735	2885867..2887198	-	1332	WP_046852509.1	type II toxin-antitoxin system HipA family toxin	Toxin
G9395_RS13740	2887198..2887470	-	273	WP_032696205.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
G9395_RS13745	2887664..2888218	-	555	WP_064793779.1	RNA polymerase sigma factor	-
G9395_RS13750	2888224..2888649	-	426	WP_032687741.1	hypothetical protein	-
G9395_RS13755	2888781..2889734	-	954	WP_032687742.1	hypothetical protein	-
G9395_RS13760	2889950..2890582	-	633	WP_064793778.1	class I SAM-dependent methyltransferase	-
G9395_RS13765	2890602..2891843	-	1242	WP_046852512.1	sensor domain-containing diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2818126..2992155	174029

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 49383.68 Da
• Isoelectric Point: 6.5066

>T191847 WP_046852509.1 NZ_CP069815:c2887198-2885867 [Raoultella planticola]
MATLVTWMNNERVGELIKQANGAHLFRYEEAWMRNPRARPLSLSLPLQYGNITDDAVFNYFDNLLPDSPRVRDRIVKRYQ
ARSKQPFDLLAEIGRDSVGAVTLLPPGENATRGALSWEALDSHALDALLTAYQSDIPLGMVNEHDDFRISVAGAQEKTAL
LKIGEQWCIPTGTTPTTHIIKLPIGEIKQPDAVLDLSESVDNEYLCLALARALGFAVPRASIIQTASIRALAVERFDRRW
AQEKTVLLRLPQEDLCQAFGIPSSIKYESDGGPGIRAIMAFLVGSSEALEDRYNFMKFMVFQWLIGATDGHAKNFSIFLQ
PGGSYRLTPFYDIISAFPLLGGKGLHLSDLRLSMSLKASKGRKTEIQTLYPRHFLATAKEVGFAEEQMLEILRYFVDNVP
HAVAAVKETLPHDFSPPVYEAITDRLLWVHSRLQNAMAALPSG

Nucleotide

• Length: 1332 bp

>T191847 NZ_CP091957:c749481-749221 [Leptospira noguchii]
GTGTCAAAAAGTGAAAAATTAATCCAAAGGTTCTTAGGACGACCTAAAGATTTTTCTTACGATGAACTTAGAAAATTATT
TTCAGGCTTTGGGTATATTGAAGATAATTCAGGTAAATCTTCTGGCTCAAGAGTTGCTTGGATTCATTCGGAGACGAAAC
ATATTATTAGACTTCATAAACCTCATCCGAAGAATATTTTGAAGTCATATCAGATAAATCAAATTTTAGATGAATTAAAA
TCGGAGGGCTATATAAAATGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10168.43 Da
• Isoelectric Point: 4.9491

>AT191847 WP_032696205.1 NZ_CP069815:c2887470-2887198 [Raoultella planticola]
MSPSPGIYSPVQLANYLKLVRQKNQWTQSDLAQRMGIKQATVSNFENHPEKTTLTTVFKILQSLELSMAICEKNAPDTND
SSDNPQDLDW

Nucleotide

• Length: 273 bp

>AT191847 NZ_CP091957:c749224-748868 [Leptospira noguchii]
ATGAAAGATATTATCGAATATAACGGCTTTTTAGGTTCTGTTCATTTTGATGCAGACGATGAAGTATTTTTTGGAAAAAT
AGAAGGAATTGAAGATTTGGTTTCCTTTGAAGGTGAATCAGTTAAACAACTGAAGAAGGCATTTCAAGAATCAGTAGATG
ATTATTTAATCTTATGCAAAAAGGCTAAAAAGAGTCCAGAGAAATCTTTTAAAGGTTCATTTAATGTTCGCATACCAACT
GAACTTCATCGACGCGTTTATAGAAAATCGTTAAGAGAAGGCATTTCTTTGAATCAATTAGTTCAGAGAGCTTTAGAAAA
AGAAATCACGGAACTTAAGACGCCACACTTCGGCTAA

Structures

Antitoxin

• AlphaFold DB: A0A2X2EM10