Detailed information of TA system TA191837

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 747521..748274
• Replicon: chromosome
• Accession: NZ_CP069815
• Organism: Raoultella planticola strain HH15

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: R8WN26
• Locus tag: G9395_RS03610
• Protein ID: WP_016154457.1
• Coordinates: 747521..747898 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: G9395_RS03615
• Protein ID: WP_162838704.1
• Coordinates: 747948..748274 (-)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9395_RS03570	742551..743036	-	486	WP_032697582.1	GNAT family N-acetyltransferase	-
G9395_RS03575	743901..744479	+	579	WP_046853455.1	TetR/AcrR family transcriptional regulator	-
G9395_RS03580	744480..744937	-	458	Protein_702	iron-containing redox enzyme family protein	-
G9395_RS03585	744888..745403	+	516	WP_081277349.1	alpha-glucosidase C-terminal domain-containing protein	-
G9395_RS03590	745611..745862	-	252	WP_143520598.1	hypothetical protein	-
G9395_RS03595	745874..746719	-	846	Protein_705	DUF4942 domain-containing protein	-
G9395_RS03600	746800..747003	-	204	WP_009652505.1	DUF957 domain-containing protein	-
G9395_RS03605	747033..747524	-	492	WP_009652438.1	hypothetical protein	-
G9395_RS03610	747521..747898	-	378	WP_016154457.1	TA system toxin CbtA family protein	Toxin
G9395_RS03615	747948..748274	-	327	WP_162838704.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
G9395_RS03620	748331..748552	-	222	WP_009652392.1	DUF987 domain-containing protein	-
G9395_RS03625	748566..749048	-	483	WP_016154455.1	DNA repair protein RadC	-
G9395_RS03630	749060..749278	-	219	WP_009652503.1	hypothetical protein	-
G9395_RS03635	749289..749750	-	462	WP_045890390.1	antirestriction protein	-
G9395_RS03640	749779..750033	-	255	WP_009652519.1	hypothetical protein	-
G9395_RS03645	750033..750851	-	819	WP_009652424.1	DUF945 domain-containing protein	-
G9395_RS03650	750955..751188	-	234	WP_009652474.1	DUF905 domain-containing protein	-
G9395_RS03655	751244..751465	-	222	WP_032950095.1	hypothetical protein	-
G9395_RS03660	751547..752059	-	513	WP_032950094.1	DUF4234 domain-containing protein	-
G9395_RS03665	752108..752578	-	471	WP_009652431.1	hypothetical protein	-
G9395_RS03670	752625..752936	-	312	WP_009652410.1	hypothetical protein	-
G9395_RS03675	752949..753215	-	267	WP_032950091.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (4-103)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14168.19 Da
• Isoelectric Point: 9.5224

>T191837 WP_016154457.1 NZ_CP069815:c747898-747521 [Raoultella planticola]
MQTQPVPPKREVSPRPSPVAIWQRLLSHLLDRHYGLTLNDTPFGKDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLTSIDILRARKATGLMTRHSYRAVTDITTGKYREVQP

Nucleotide

• Length: 378 bp

>T191837 NZ_CP091943:c735830-735489 [Leptospira noguchii]
ATGATTCGTGGTGAGATCTGGTGGGTGGACTTAGGAATTCCATTTGGAAGTGAACCTGGATTTAAGAGACCCGTTTTGAT
TATTCAAGATGACTCTTTTAATCAAAGTAGTATCAGTACTGTAGTATCGATTGCGATTACATCAAATTTAAATTTGTCTG
AAGCTCCTGGCAATGTTCTGATCAGTAAGAAAGAATCCAGCTTATCAAAAGATTCAGTTGTGAATGTCTCTCAAATCGTG
ACTTTAGATAAAGAGAGATTCATTAAACGGGCGGGAAAGCTTAAATCAAGTAAGATCAACGAAGTTGAAACAGGCCTCAA
GTTAGTTACAGGCTTAAATTAA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12079.85 Da
• Isoelectric Point: 6.6283

>AT191837 WP_162838704.1 NZ_CP069815:c748274-747948 [Raoultella planticola]
IAAPWWGLKRDITPCFGARLVQEGNRLHYLNDRASITGTFSDADLRHLDQAFPLLLKQLELMLLSGELNPRHQHCVTLYA
KGLICEADSLGSHGYVYLAIYPTPATTE

Nucleotide

• Length: 327 bp

>AT191837 NZ_CP091943:c736065-735817 [Leptospira noguchii]
ATGAAAACTGCGATTTCGATTCCAGATGAGTTATTCAAGACTGCTGAGAAAATAGCAAAAAAACTTGGAATACCTCGAAG
TCAGCTTTTTGCAAAGGCATTAGAAGAATTTATTCAATCCCATAGTAAAGAATCTATAACTGAGAAGTTAAATAAAGTTT
ATAGCAATAAATCCAAAGAGCTTAAAAGTAATATCGTAGATTTATCCGTAGAATCACTGCGTAAGAGTTTAAAAAATGAT
TCGTGGTGA

Structures

Toxin

• AlphaFold DB: R8WN26