Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2042191..2042861 Replicon chromosome
Accession NZ_CP069812
Organism Cupriavidus oxalaticus strain Ox1

Toxin (Protein)


Gene name vapC Uniprot ID A0A375G4I0
Locus tag JTE92_RS21815 Protein ID WP_063237843.1
Coordinates 2042191..2042610 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A375FZF0
Locus tag JTE92_RS21820 Protein ID WP_063237844.1
Coordinates 2042607..2042861 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTE92_RS21790 2037454..2038155 + 702 WP_063237839.1 protocatechuate 3,4-dioxygenase subunit beta -
JTE92_RS21795 2038160..2038729 + 570 WP_063237840.1 protocatechuate 3,4-dioxygenase subunit alpha -
JTE92_RS21800 2038788..2040176 + 1389 WP_084254485.1 3-carboxy-cis,cis-muconate cycloisomerase -
JTE92_RS21805 2040214..2041404 + 1191 WP_063237842.1 3-oxoadipate enol-lactonase -
JTE92_RS21810 2041456..2042085 - 630 WP_084254486.1 2'-5' RNA ligase family protein -
JTE92_RS21815 2042191..2042610 - 420 WP_063237843.1 type II toxin-antitoxin system VapC family toxin Toxin
JTE92_RS21820 2042607..2042861 - 255 WP_063237844.1 Arc family DNA-binding protein Antitoxin
JTE92_RS21825 2043297..2043854 - 558 WP_174544843.1 hypothetical protein -
JTE92_RS21830 2043867..2044109 - 243 WP_174544844.1 hypothetical protein -
JTE92_RS21835 2044198..2044926 - 729 WP_063237845.1 hypothetical protein -
JTE92_RS21840 2045067..2045198 - 132 Protein_1878 DUF2274 domain-containing protein -
JTE92_RS21845 2045353..2046303 - 951 WP_063237846.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
JTE92_RS21850 2046287..2047111 - 825 WP_063237847.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14836.02 Da        Isoelectric Point: 5.6468

>T191836 WP_063237843.1 NZ_CP069812:c2042610-2042191 [Cupriavidus oxalaticus]
MIVLDTNVVSEAMKPEPSPAVQAWLNEQVAETLYLSSVTLAELLFGIGALPNGKRKKGLGEALDGLLELFGERVLMFDTE
AARHYAELAAKARTAGKGFPTPHGYIGAIAASKGFIVATRDTSPFEAAGLTVINPWNHQ

Download         Length: 420 bp

>T191836 NZ_CP091942:45920-46261 [Leptospira noguchii]
TTGGTAAAGAATAGAAATTATACTCCTGAAAAAGGAGATATTGTGTGGCTGAACTTTACTCCTCAAGCAGGTCATGAACA
GAAAGGTCGTAGACCTGCACTTGTTTTATCGCCTAAGGAATATAATTCAAAGACAGGGTTAGCAATATTTTGTCCAATTA
CCAGTAAAATTAAAGGTTATCCATTCGAAGTGTTGATTAAATCAAAAAAAATCGATGGTGTAATTCTTTCTGATCAAGTA
AAAAACTTAGATTGGACTATCCGTGAAGCAGAATTTATTGAATCAATAAATAAAGTTTCTTTAAAAGAAGTTTTAGATAA
TATTAAATTATTAATATTCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9450.83 Da        Isoelectric Point: 7.2071

>AT191836 WP_063237844.1 NZ_CP069812:c2042861-2042607 [Cupriavidus oxalaticus]
MAILTVRNVPDEVHRALRLRAAEHGRSTEAEVRAILESAVKSEKRIRMGDALAELGRRVGLTNDDFAVLDQVRDKVPAEP
MRFE

Download         Length: 255 bp

>AT191836 NZ_CP091942:45690-45926 [Leptospira noguchii]
ATGGAATCAATTATTCAAAAATGGGGTAATAGCTTAGGAATTAGAATTCCAAAAGCAATGGCAACGGAATTAGAGTTAAA
TGATGGAAGCCATGTTGAATTACAATATGAAGGAGATAAGATTGTAATATATCCAATGAAAAAAGCTTCATTGGAAGATA
AACTTTCTAAAATTACGAAACAAAATCTTCACTCTGAAATATCTACTGGTAATTCTATAGGCAATGAAGCTTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A375G4I0

Antitoxin

Source ID Structure
AlphaFold DB A0A375FZF0

References