Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1937176..1938887 Replicon chromosome
Accession NZ_CP069812
Organism Cupriavidus oxalaticus strain Ox1

Toxin (Protein)


Gene name hipA Uniprot ID A0A375G1E4
Locus tag JTE92_RS21340 Protein ID WP_063238760.1
Coordinates 1937559..1938887 (+) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A375G3G0
Locus tag JTE92_RS21335 Protein ID WP_063238761.1
Coordinates 1937176..1937556 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTE92_RS21315 1934924..1935235 + 312 WP_063238764.1 response regulator transcription factor -
JTE92_RS21320 1935274..1935921 - 648 WP_063238763.1 response regulator transcription factor -
JTE92_RS21325 1935968..1936828 - 861 WP_063238762.1 universal stress protein -
JTE92_RS21330 1936886..1936978 - 93 Protein_1776 hypothetical protein -
JTE92_RS21335 1937176..1937556 + 381 WP_063238761.1 helix-turn-helix domain-containing protein Antitoxin
JTE92_RS21340 1937559..1938887 + 1329 WP_063238760.1 type II toxin-antitoxin system HipA family toxin Toxin
JTE92_RS21345 1939012..1942555 + 3544 Protein_1779 AAA family ATPase -
JTE92_RS21350 1942552..1943223 + 672 WP_063238758.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-66)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 48691.54 Da        Isoelectric Point: 7.5369

>T191835 WP_063238760.1 NZ_CP069812:1937559-1938887 [Cupriavidus oxalaticus]
MTRGTHAKRLDLWMNGLPVGHWETAPAGDRLAYREDWIADPQGRPLSLSLPFTPGNQPHRGPVVANYFDNLLPDSDAIRR
RIAARYQTGGTDAFALLARLGRDCAGALQMLPPQEAPMALKRVQGRPLSETEIATLLHEATAEPVLGLREPIDDLRLSIA
GAQEKTALLRWDGQWLLPQGSTPTTHIFKLPMGLVGNMRADMRTSVENEWLCARIVAAFGLPVAACEIARFGDTKALVVE
RFDRKPSADGSWLLRLPQEDMCQATGTSALQKYESDGGPGIQQIADILSGSRSALSDRRNFFLAQIVFWLLAATDGHGKN
FSISHLPGSRYEATPLYDILSAHPIIGKGKNQVAPQRARLAMALHGKNSHYAIQEIQRRHWFAQGQRIGFSPDDVESMLD
EVMSQTSRAIDAAASALPPEFPMDLADAIFDGMRRQQRRLAA

Download         Length: 1329 bp

>T191835 NZ_CP091940:c728773-728432 [Leptospira noguchii]
ATGATTCGTGGTGAGATCTGGTGGGTGGACTTAGGAATTCCATTTGGAAGTGAACCTGGATTTAAGCGACCCGTTTTGAT
TATTCAAGATGACTCTTTTAATCAAAGTAGTATCAGTACTGTAGTATCGATTGCGATTACATCAAATTTAAATTTGTCTG
AAGCTCCTGGCAATGTTCTGATCAGTAAGAAAGAATCCAGCTTATCAAAAGATTCAGTTGTGAATGTCTCTCAAATCGTG
ACTTTAGATAAAGAGAGATTCATTAAACGGGCGGGAAAGCTTAAATCAAGTAAGATCAACGAAGTTGAAACAGGCCTCAA
GTTAGTTACAGGCTTAAATTAA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 14011.01 Da        Isoelectric Point: 10.1702

>AT191835 WP_063238761.1 NZ_CP069812:1937176-1937556 [Cupriavidus oxalaticus]
MHYSIQTLSQLRPILQGFRKSRGLTQANMAAYLGVRQQTYAELEANPAAASVERLFKALRVLGVEMVLSPAPDTAMQPEP
EPPSGSVTPPEKDPRRATQEEQPKMPAKRKASRTALETGQPKREDW

Download         Length: 381 bp

>AT191835 NZ_CP091940:c729008-728760 [Leptospira noguchii]
ATGAAAACTGCGATTTCGATTCCAGATGAGTTATTCAAGACTGCTGAGAAAATAGCAAAAAAACTTGGAATACCTCGAAG
TCAGCTTTTTGCAAAGGCATTAGAAGAATTTATTCAATCCCATAGTAAAGAATCTATAACTGAGAAGTTAAATAAAGTTT
ATAGCAATAAATCCAAAGAGCTTAAAAGTAATATCGTAGATTTATCCGTAGAATCACTGCGTAAGAGTTTAAAAAATGAT
TCGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A375G1E4

Antitoxin

Source ID Structure
AlphaFold DB A0A375G3G0

References