Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 669815..670380 Replicon chromosome
Accession NZ_CP069812
Organism Cupriavidus oxalaticus strain Ox1

Toxin (Protein)


Gene name vapC Uniprot ID A0A375GDJ8
Locus tag JTE92_RS15430 Protein ID WP_063236949.1
Coordinates 670009..670380 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A375GBB0
Locus tag JTE92_RS15425 Protein ID WP_063236948.1
Coordinates 669815..670012 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTE92_RS15410 665402..666370 - 969 WP_063236945.1 formimidoylglutamase -
JTE92_RS15415 666367..667686 - 1320 WP_063236946.1 MFS transporter -
JTE92_RS15420 667883..669553 - 1671 WP_063236947.1 urocanate hydratase -
JTE92_RS15425 669815..670012 + 198 WP_063236948.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JTE92_RS15430 670009..670380 + 372 WP_063236949.1 type II toxin-antitoxin system VapC family toxin Toxin
JTE92_RS15435 670431..671147 - 717 WP_063236950.1 histidine utilization repressor -
JTE92_RS15440 671183..674572 - 3390 WP_063236951.1 diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-46)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13208.25 Da        Isoelectric Point: 5.9661

>T191834 WP_063236949.1 NZ_CP069812:670009-670380 [Cupriavidus oxalaticus]
MILVDTSVWIDHLRTGDAALAALLDASRVLVHPFVIGEIALGSLRQRGEVLGALRDLPGAVVATDDEVDRMIDDQKLYGI
GIGYVDAHLLAATRLTPGSALWTRDRRLLAVAEHLGLAARPAH

Download         Length: 372 bp

>T191834 NZ_CP091936:c776308-775967 [Leptospira noguchii]
ATGATTCGTGGTGAGATCTGGTGGGTGGACTTAGGAATTCCATTTGGAAGTGAACCTGGATTTAAGCGACCCGTTTTGAT
TATTCAAGATGACTCTTTTAATCAAAGTAGTATCAGTACTGTAGTATCGATTGCGATTACATCAAATTTAAATTTGTCTG
AAGCTCCTGGCAATGTTCTGATCAGTAAGAAAGAATCCAGCTTATCAAAAGATTCAGTTGTGAATGTCTCTCAAATCGTG
ACTTTAGATAAAGAGAGATTCATTAAACGGGCGGGAAAGCTTAAATCAAGTAAGATCAACGAAGTTGAAACAGGCCTCAA
GTTAGTTACAGGCTTAAATTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7215.22 Da        Isoelectric Point: 10.6625

>AT191834 WP_063236948.1 NZ_CP069812:669815-670012 [Cupriavidus oxalaticus]
MRTTLALDDDLLRKAQALTGLSEKSSLVREALRALIERESARRLSRLGGTEPDLESAPRRRAEPA

Download         Length: 198 bp

>AT191834 NZ_CP091936:c776543-776295 [Leptospira noguchii]
ATGAAAACTGCGATTTCGATTCCAGATGAGTTATTCAAGACTGCTGAGAAAATAGCAAAAAAACTTGGAATACCTCGAAG
TCAGCTTTTTGCAAAGGCATTAGAAGAATTTATTCAATCCCATAGTAAAGAATCTATAACTGAGAAGTTAAATAAAGTTT
ATAGCATTAAATCCAAAGAGCTTAAAAGTAATATCGCAGATTTATCCGTAGAATCACTGCGTAAGAGTTTAAAAAATGAT
TCGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A375GDJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A375GBB0

References