191832

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT_toxin-BrnA
Location 1799603..1800143 Replicon chromosome
Accession NZ_CP069811
Organism Cupriavidus oxalaticus strain Ox1

Toxin (Protein)


Gene name brnT Uniprot ID A0A375GHM6
Locus tag JTE92_RS07915 Protein ID WP_063240620.1
Coordinates 1799603..1799872 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID A0A375GNI1
Locus tag JTE92_RS07920 Protein ID WP_063240621.1
Coordinates 1799856..1800143 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTE92_RS07895 1794714..1795424 - 711 WP_063240616.1 uracil phosphoribosyltransferase -
JTE92_RS07900 1795524..1796846 - 1323 WP_063240617.1 URC4/urg3 family protein -
JTE92_RS07905 1796843..1798081 - 1239 WP_063240618.1 GTP cyclohydrolase II -
JTE92_RS07910 1798315..1799424 - 1110 WP_063240619.1 acyltransferase -
JTE92_RS07915 1799603..1799872 + 270 WP_063240620.1 BrnT family toxin Toxin
JTE92_RS07920 1799856..1800143 + 288 WP_063240621.1 BrnA antitoxin family protein Antitoxin
JTE92_RS07925 1800381..1800689 + 309 WP_063240622.1 hypothetical protein -
JTE92_RS07930 1800759..1801661 - 903 WP_063240623.1 hypothetical protein -
JTE92_RS07935 1802063..1803802 + 1740 WP_063240624.1 glycosyltransferase family 39 protein -
JTE92_RS07940 1803822..1804193 + 372 WP_063240625.1 EamA family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-81)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(27-90)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10139.59 Da        Isoelectric Point: 8.0323

>T191832 WP_063240620.1 NZ_CP069811:1799603-1799872 [Cupriavidus oxalaticus]
MDITFDVAKDAANLSKHGLSLRVAAQLDWPAVMAGVDTRRDYREVREIGFGVIADRLYCVVFTQRGDAMHIISLRKANQR
EVRNYVEQT

Download         Length: 270 bp

>T191832 NZ_CP091928:c735772-735431 [Leptospira noguchii]
ATGATTCGTGGTGAGATCTGGTGGGTGGACTTAGGAATTCCATTTGGAAGTGAACCTGGATTTAAGAGACCCGTTTTGAT
TATTCAAGATGACTCTTTTAATCAAAGTAGTATCAGTACTGTAGTATCGATTGCGATTACATCAAATTTAAATTTGTCTG
AAGCTCCTGGCAATGTTCTGATCAGTAAGAAAGAATCCAGCTTATCAAAAGATTCAGTTGTGAATGTCTCTCAAATCGTG
ACTTTAGATAAAGAGAGATTCATTAAACGGGCGGGAAAGCTTAAATCAAGTAAGATCAACGAAGTTGAAACAGGCCTCAA
GTTAGTTACAGGCTTAAATTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10721.20 Da        Isoelectric Point: 8.5541

>AT191832 WP_063240621.1 NZ_CP069811:1799856-1800143 [Cupriavidus oxalaticus]
MSSKPKIVMPTDEEDAAINRGIATDPDTYEVSADEMMAMKPLGKRGRGRPRLGNTKELVSIRYDAEVLEAFRASGEGWQT
RMNSALKEWLRTHRP

Download         Length: 288 bp

>AT191832 NZ_CP091928:c736007-735759 [Leptospira noguchii]
ATGAAAACTGCGATTTCGATTCCAGATGAGTTATTCAAGACTGCTGAGAAAATAGCAAAAAAACTTGGAATACCTCGAAG
TCAGCTTTTTGCAAAGGCATTAGAAGAATTTATTCAATCCCATAGTAAAGAATCTATAACTGAGAAGTTAAATAAAGTTT
ATAGCAATAAATCCAAAGAGCTTAAAAGTAATATCGTAGATTTATCCGTAGAATCACTGCGTAAGAGTTTAAAAAATGAT
TCGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A375GHM6

Antitoxin

Source ID Structure
AlphaFold DB A0A375GNI1

References