Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3116262..3116827 Replicon chromosome
Accession NZ_CP069810
Organism Cupriavidus oxalaticus strain Ox1_mCherry

Toxin (Protein)


Gene name vapC Uniprot ID A0A375GDJ8
Locus tag JTE91_RS26830 Protein ID WP_063236949.1
Coordinates 3116262..3116633 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A375GBB0
Locus tag JTE91_RS26835 Protein ID WP_063236948.1
Coordinates 3116630..3116827 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTE91_RS26820 3112070..3115459 + 3390 WP_063236951.1 diguanylate cyclase -
JTE91_RS26825 3115495..3116211 + 717 WP_063236950.1 histidine utilization repressor -
JTE91_RS26830 3116262..3116633 - 372 WP_063236949.1 type II toxin-antitoxin system VapC family toxin Toxin
JTE91_RS26835 3116630..3116827 - 198 WP_063236948.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JTE91_RS26840 3117089..3118759 + 1671 WP_063236947.1 urocanate hydratase -
JTE91_RS26845 3118956..3120275 + 1320 WP_063236946.1 MFS transporter -
JTE91_RS26850 3120272..3121240 + 969 WP_063236945.1 formimidoylglutamase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-46)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13208.25 Da        Isoelectric Point: 5.9661

>T191829 WP_063236949.1 NZ_CP069810:c3116633-3116262 [Cupriavidus oxalaticus]
MILVDTSVWIDHLRTGDAALAALLDASRVLVHPFVIGEIALGSLRQRGEVLGALRDLPGAVVATDDEVDRMIDDQKLYGI
GIGYVDAHLLAATRLTPGSALWTRDRRLLAVAEHLGLAARPAH

Download         Length: 372 bp

>T191829 NZ_CP091926:c91160-89835 [Escherichia coli]
ATGAGCCGGAAACAGCAACGTCTGGTAATTTGGATGAACGGCATCAAAGTCGGGTACTGGGAAAAAAGCAAAGGGGTAGA
CAGCTTAGAATACCTTCCTGAATGGGTTGCTGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTGCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTGCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACTGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGATCGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGAGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGGCCAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAGACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCGTTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAGGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAATTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCAAACTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTGGCAGAAGTGCAAACTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCGGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7215.22 Da        Isoelectric Point: 10.6625

>AT191829 WP_063236948.1 NZ_CP069810:c3116827-3116630 [Cupriavidus oxalaticus]
MRTTLALDDDLLRKAQALTGLSEKSSLVREALRALIERESARRLSRLGGTEPDLESAPRRRAEPA

Download         Length: 198 bp

>AT191829 NZ_CP091926:c91458-91165 [Escherichia coli]
ATCAATAATGATTACCCGTTAAACACGCTCAACCAGCTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGCGTCACTCAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCCATCCTGGGCGTAAAAATCAGCTTCTCCTCGGCAACCACCTCTTCAGAGAGGAAG
CAGACGGAAGAAATGCTTAAATCAAACTCACCTGCACGACAGGAGGATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A375GDJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A375GBB0

References