Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1847757..1849468 Replicon chromosome
Accession NZ_CP069810
Organism Cupriavidus oxalaticus strain Ox1_mCherry

Toxin (Protein)


Gene name hipA Uniprot ID A0A375G1E4
Locus tag JTE91_RS20920 Protein ID WP_063238760.1
Coordinates 1847757..1849085 (-) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A375G3G0
Locus tag JTE91_RS20925 Protein ID WP_063238761.1
Coordinates 1849088..1849468 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTE91_RS20910 1843419..1844090 - 672 WP_063238758.1 hypothetical protein -
JTE91_RS20915 1844087..1847632 - 3546 WP_063238759.1 adenylate/guanylate cyclase domain-containing protein -
JTE91_RS20920 1847757..1849085 - 1329 WP_063238760.1 type II toxin-antitoxin system HipA family toxin Toxin
JTE91_RS20925 1849088..1849468 - 381 WP_063238761.1 helix-turn-helix domain-containing protein Antitoxin
JTE91_RS20930 1849666..1849758 + 93 Protein_1674 hypothetical protein -
JTE91_RS20935 1849816..1850676 + 861 WP_063238762.1 universal stress protein -
JTE91_RS20940 1850723..1851370 + 648 WP_063238763.1 response regulator transcription factor -
JTE91_RS20945 1851409..1851720 - 312 WP_063238764.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - acrB 1817609..2182102 364493


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-66)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 48691.54 Da        Isoelectric Point: 7.5369

>T191828 WP_063238760.1 NZ_CP069810:c1849085-1847757 [Cupriavidus oxalaticus]
MTRGTHAKRLDLWMNGLPVGHWETAPAGDRLAYREDWIADPQGRPLSLSLPFTPGNQPHRGPVVANYFDNLLPDSDAIRR
RIAARYQTGGTDAFALLARLGRDCAGALQMLPPQEAPMALKRVQGRPLSETEIATLLHEATAEPVLGLREPIDDLRLSIA
GAQEKTALLRWDGQWLLPQGSTPTTHIFKLPMGLVGNMRADMRTSVENEWLCARIVAAFGLPVAACEIARFGDTKALVVE
RFDRKPSADGSWLLRLPQEDMCQATGTSALQKYESDGGPGIQQIADILSGSRSALSDRRNFFLAQIVFWLLAATDGHGKN
FSISHLPGSRYEATPLYDILSAHPIIGKGKNQVAPQRARLAMALHGKNSHYAIQEIQRRHWFAQGQRIGFSPDDVESMLD
EVMSQTSRAIDAAASALPPEFPMDLADAIFDGMRRQQRRLAA

Download         Length: 1329 bp

>T191828 NZ_CP091925:c4282157-4281984 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 14011.01 Da        Isoelectric Point: 10.1702

>AT191828 WP_063238761.1 NZ_CP069810:c1849468-1849088 [Cupriavidus oxalaticus]
MHYSIQTLSQLRPILQGFRKSRGLTQANMAAYLGVRQQTYAELEANPAAASVERLFKALRVLGVEMVLSPAPDTAMQPEP
EPPSGSVTPPEKDPRRATQEEQPKMPAKRKASRTALETGQPKREDW

Download         Length: 381 bp

>AT191828 NZ_CP091925:c4282481-4282185 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A375G1E4

Antitoxin

Source ID Structure
AlphaFold DB A0A375G3G0

References