Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2154392..2154906 Replicon chromosome
Accession NZ_CP069799
Organism Staphylococcus aureus strain 014S_SA

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag JS513_RS10760 Protein ID WP_000581792.1
Coordinates 2154392..2154601 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag JS513_RS10765 Protein ID WP_000138932.1
Coordinates 2154613..2154906 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JS513_RS10740 2149900..2151258 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
JS513_RS10745 2151273..2152343 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
JS513_RS10750 2152661..2153863 + 1203 WP_001109941.1 rod shape-determining protein RodA -
JS513_RS10755 2154127..2154264 - 138 WP_000828354.1 hypothetical protein -
JS513_RS10760 2154392..2154601 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
JS513_RS10765 2154613..2154906 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
JS513_RS10770 2155072..2156556 + 1485 WP_000571549.1 cardiolipin synthase -
JS513_RS10775 2156584..2157231 + 648 WP_001187629.1 HD domain-containing protein -
JS513_RS10780 2157703..2158575 - 873 WP_000725802.1 membrane protein insertase YidC -
JS513_RS10785 2158661..2159302 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T191818 WP_000581792.1 NZ_CP069799:c2154601-2154392 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T191818 NZ_CP091925:2279840-2280127 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT191818 WP_000138932.1 NZ_CP069799:c2154906-2154613 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT191818 NZ_CP091925:2279601-2279840 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References