Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 851983..852460 Replicon chromosome
Accession NZ_CP069799
Organism Staphylococcus aureus strain 014S_SA

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag JS513_RS04100 Protein ID WP_000052076.1
Coordinates 851983..852171 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag JS513_RS04105 Protein ID WP_001059690.1
Coordinates 852200..852460 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JS513_RS04070 847974..848495 + 522 WP_000824484.1 hypothetical protein -
JS513_RS04075 848836..849522 + 687 WP_000141557.1 thermonuclease family protein -
JS513_RS04080 849879..850079 + 201 WP_001059082.1 cold-shock protein -
JS513_RS04085 850574..850792 - 219 WP_000005884.1 hypothetical protein -
JS513_RS04090 850854..851138 - 285 WP_001004399.1 hypothetical protein -
JS513_RS04095 851226..851795 - 570 WP_001106655.1 hypothetical protein -
JS513_RS04100 851983..852171 - 189 WP_000052076.1 hypothetical protein Toxin
JS513_RS04105 852200..852460 - 261 WP_001059690.1 hypothetical protein Antitoxin
JS513_RS04110 852801..853004 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
JS513_RS04115 853001..853237 - 237 WP_000368687.1 hypothetical protein -
JS513_RS04120 853462..854043 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
JS513_RS04125 854116..854733 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
JS513_RS04130 854888..855382 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
JS513_RS04135 855781..856203 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
JS513_RS04140 856351..857067 + 717 WP_000150018.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Domain of unknown function DUF5615

(1-78)

Antitoxin

Protein of unknown function DUF433

(8-63)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T191807 WP_000052076.1 NZ_CP069799:c852171-851983 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T191807 NZ_CP091913:5815319-5815657 [Nostoc sp. UHCC 0870]
ATGACAATCTGGATAGATGCACATTTATCGCCTACCATTGCGACTTGGATCAGCAACACTTTTGGTATAACAGCTTTAGC
TTTACGCGATGTTGGCCTGAGAGACGCTGAAGACCTTGAGATTTTTGAGGTAGCAAAAACTCAAGGAGTTATCTTTATAA
CTAAGGATAGCGACTTTGTTGACTTGGTTGAGCGTCTGGGAACACCTCCGCAAATTATCTGGTTAACTTGCGGAAATACA
TCAAATTCTCGGTTACAAGAGATTTTAATTGCTACTTTGCCAAAAGCATTAGAGCTTTTGCGAACAGGTGAAAAGTTAGT
TGAAATCAGTGGAGAATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT191807 WP_001059690.1 NZ_CP069799:c852460-852200 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT191807 NZ_CP091913:5815098-5815322 [Nostoc sp. UHCC 0870]
ATGTCCAACTTACTGAGCAGAATTACAGTTAATCCCAAACAATGCGGCGGTCGCCCATGTATTCGAGGGATGAGAATTAG
GGTGTCAGATGTATTAGACTTATTTGCTGCTGGACTTAATGCAGAACAAATATTAGAAGAAATGCCTGATCTAGAAGCAG
ATGATCTCAAAGCAGCACTACTATATGCTTCGCGGAAGCTCAATCATCCAGTGTTAGTAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References