Detailed information of TA system TA191805

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2367403..2367931
• Replicon: chromosome
• Accession: NZ_CP069798
• Organism: Paralysiella testudinis strain 26B

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JQU52_RS12110
• Protein ID: WP_230338735.1
• Coordinates: 2367403..2367699 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JQU52_RS12115
• Protein ID: WP_230338736.1
• Coordinates: 2367689..2367931 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQU52_RS12090 (JQU52_12095)	2362908..2363900	-	993	WP_268866616.1	CDF family Co(II)/Ni(II) efflux transporter DmeF	-
JQU52_RS12095 (JQU52_12100)	2363919..2364809	-	891	WP_230338733.1	NAD(+) kinase	-
JQU52_RS12100 (JQU52_12105)	2365641..2366591	+	951	WP_230340580.1	tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA	-
JQU52_RS12105 (JQU52_12110)	2366607..2367131	+	525	WP_230338734.1	RDD family protein	-
JQU52_RS12110 (JQU52_12115)	2367403..2367699	-	297	WP_230338735.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JQU52_RS12115 (JQU52_12120)	2367689..2367931	-	243	WP_230338736.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
JQU52_RS12120 (JQU52_12125)	2367997..2368713	-	717	WP_230338737.1	hypothetical protein	-
JQU52_RS12125 (JQU52_12130)	2368673..2369437	+	765	WP_230338738.1	hypothetical protein	-
JQU52_RS12130 (JQU52_12135)	2369434..2369505	+	72	Protein_2368	single-stranded DNA-binding protein	-
JQU52_RS12135 (JQU52_12140)	2369568..2369789	+	222	WP_230338739.1	hypothetical protein	-
JQU52_RS12140 (JQU52_12145)	2369784..2370548	-	765	WP_230338740.1	IS5 family transposase	-
JQU52_RS12145 (JQU52_12150)	2370613..2371002	+	390	WP_230338741.1	tyrosine-type recombinase/integrase	-
JQU52_RS12150 (JQU52_12155)	2371144..2371809	-	666	WP_230338742.1	HAD family hydrolase	-
JQU52_RS12155 (JQU52_12160)	2371806..2372480	-	675	WP_230338743.1	DnaA regulatory inactivator Hda	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-67)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11054.95 Da
• Isoelectric Point: 10.5099

>T191805 WP_230338735.1 NZ_CP069798:c2367699-2367403 [Paralysiella testudinis]
MTYKLAFLPSALREWAKLDGSIKTQFKHKLAERLTHPHVPASALRGMHNAYKIKLRQAGFRLVYTVDDGLITVTVVAVGK
RDKNAVYVQAMARMDEEA

Nucleotide

• Length: 297 bp

>T191805 NZ_CP091913:c5175212-5174868 [Nostoc sp. UHCC 0870]
ATGAAGCGTGGTGATATTTATTACGCTAATCTCAGTCGGACTTTAGGCTCTGAGATGGATAAACGCCGCCCAGTGCTGAT
AGTTAGCAATGATGCTAATAATCGCGCAGCTAGCACGGTAACAATTTTACCCCTTACATCCAATGTCAGCCGTGTTTACC
CCTTCGAGGTTTTACTGAATCCAGAAGATAGTGGTTTACCATTAGCGTCCAAAGTACAGGCGCAGCAGGTAAGAACAATT
TCCAAGCAAAGGATTGTGTCAGAGGTGGTAAATAGTTTAAGTGAAGAGTTGATGCAATTAGTAGATGCGTCTCTCAAACT
ACATTTAGAGTTGGAGAAAAGGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8738.99 Da
• Isoelectric Point: 4.1074

>AT191805 WP_230338736.1 NZ_CP069798:c2367931-2367689 [Paralysiella testudinis]
MEAVLADYAVSVTELKRNFAAIVAQADGAVAVLNHNKPEAYLISAQRYQALLAYLEDLEDAKLVQERMGETAVMVALDDL

Nucleotide

• Length: 243 bp

>AT191805 NZ_CP091913:c5175423-5175199 [Nostoc sp. UHCC 0870]
ATGCAAGTTGAAAAGCTATCAATTTCCTTACCAGCTTCCCTGGTGCAATTTATTGAAGGTTACAAAGTAGCCCATGAATG
TAAATCTCGCTCCCAAGTCATTGAAAAAGCATTGCAGTTGTTGCGAACACAGGAACTAGAACAGGCTTACCGAGAAGCAT
CTGCGGAAGTTGACAATGATTGGGAAATCACGATTACAGATGGATTAACTGATGAAGCGTGGTGA