Detailed information of TA system TA191804

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1239320..1239839
• Replicon: chromosome
• Accession: NZ_CP069798
• Organism: Paralysiella testudinis strain 26B

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: JQU52_RS06375
• Protein ID: WP_230340295.1
• Coordinates: 1239552..1239839 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: JQU52_RS06370
• Protein ID: WP_230340294.1
• Coordinates: 1239320..1239559 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQU52_RS06325 (JQU52_06355)	1234762..1235235	+	474	WP_230340111.1	single-stranded DNA-binding protein	-
JQU52_RS06330 (JQU52_06360)	1235245..1235760	+	516	WP_230340288.1	hypothetical protein	-
JQU52_RS06335	1235750..1236148	+	399	WP_230340534.1	transglycosylase SLT domain-containing protein	-
JQU52_RS06340	1236314..1236547	+	234	WP_230340289.1	hypothetical protein	-
JQU52_RS06345 (JQU52_06370)	1236756..1237067	+	312	WP_230340114.1	hypothetical protein	-
JQU52_RS06350	1237077..1237271	+	195	WP_230340290.1	hypothetical protein	-
JQU52_RS06355	1237418..1237639	+	222	WP_230340291.1	hypothetical protein	-
JQU52_RS06360	1237664..1238737	+	1074	WP_230340292.1	hypothetical protein	-
JQU52_RS06365	1238712..1239182	+	471	WP_230340293.1	hypothetical protein	-
JQU52_RS06370 (JQU52_06385)	1239320..1239559	+	240	WP_230340294.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
JQU52_RS06375 (JQU52_06390)	1239552..1239839	+	288	WP_230340295.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JQU52_RS06385 (JQU52_06400)	1240439..1240939	-	501	Protein_1234	transposase	-
JQU52_RS06390 (JQU52_06405)	1241060..1241929	+	870	WP_230340296.1	hypothetical protein	-
JQU52_RS06395 (JQU52_06410)	1242245..1242799	+	555	Protein_1236	DDE-type integrase/transposase/recombinase	-
JQU52_RS06400 (JQU52_06415)	1242759..1243574	+	816	WP_230340297.1	hypothetical protein	-
JQU52_RS06405 (JQU52_06420)	1243549..1243926	+	378	WP_230340298.1	hypothetical protein	-
JQU52_RS06410 (JQU52_06425)	1244166..1244435	+	270	WP_230340299.1	antitoxin VbhA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1240439..1240945	506

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-90)

Antitoxin

• Antitoxin ParD (3-71)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11053.49 Da
• Isoelectric Point: 5.4875

>T191804 WP_230340295.1 NZ_CP069798:1239552-1239839 [Paralysiella testudinis]
MAKPYRLSPLAEADLEEIWLYTLENWSIEQADTYHNGFVAAFEGLAAGTKQGRPSVLPNFQKYFCGSHVIYFLEYADHLD
VIRILHQRQDVERHL

Nucleotide

• Length: 288 bp

>T191804 NZ_CP091913:4938751-4939017 [Nostoc sp. UHCC 0870]
ATGACTAGAAAGCTAGCATGGACGAATGAGGCTTGGAATGATTATTTATATTGGCAAGAGCAAGACAAGAAAACATTAAA
ACGAATTAACAAGCTGATTGAAGCAACAATCCGACTACCGTTTGAGGGTATCGGTAAGCCAGAAGCACTGAGGGAAAATC
TAGCTGGCTTTTGGTCGCGGCGAATTGATCACACGAATCGGTTGGTTTATGCGGTGGATGATGAGTATTTAACGATTATT
GCTTGTCGATACCACTATTCTGATTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8713.66 Da
• Isoelectric Point: 6.4745

>AT191804 WP_230340294.1 NZ_CP069798:1239320-1239559 [Paralysiella testudinis]
MRNTSVSLGQHFTNFIDVQVQGGRYGSASDVIRAGLRLLEEHESRVKALQDALDAGCQSGEPEPFNSETFLNRMHAKHG

Nucleotide

• Length: 240 bp

>AT191804 NZ_CP091913:4938504-4938758 [Nostoc sp. UHCC 0870]
ATGAAAATCGTCTCATTTAGCGAAGCGAGAAATAACCTCAAGGCTGTTTTAGATCGAGTGGTAGAAGATACCGACTATAC
AATCATCACCAGACGGGATGCGGAGGATACTGTGGTGATGTCACTAGAGTTATTTAATAGTTTGCTGGAAACTGTTCATT
TGCTAAATTCTCCCGCTAATGCTGCCCATTTGGAGCGTTCTATTGCTCAGTTCAAGCAAGGGAAAGTAGTGGAGCGAGAT
TTGTTGGATGACTAG