Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 1114423..1114976 Replicon chromosome
Accession NZ_CP069798
Organism Paralysiella testudinis strain 26B

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag JQU52_RS05705 Protein ID WP_230340174.1
Coordinates 1114650..1114976 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag JQU52_RS05700 Protein ID WP_230340173.1
Coordinates 1114423..1114653 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQU52_RS05665 (JQU52_05695) 1109613..1110026 + 414 WP_230340166.1 DUF4878 domain-containing protein -
JQU52_RS05670 (JQU52_05700) 1110080..1110709 + 630 WP_230340167.1 YiiX/YebB-like N1pC/P60 family cysteine hydrolase -
JQU52_RS05675 (JQU52_05705) 1110746..1111165 - 420 WP_230340168.1 type II toxin-antitoxin system VapC family toxin -
JQU52_RS05680 (JQU52_05710) 1111165..1111437 - 273 WP_230340169.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
JQU52_RS05685 (JQU52_05715) 1111947..1112555 - 609 WP_230340170.1 hypothetical protein -
JQU52_RS05690 (JQU52_05720) 1112746..1112991 - 246 WP_230340171.1 helix-turn-helix transcriptional regulator -
JQU52_RS05695 (JQU52_05725) 1113090..1113725 + 636 WP_230340172.1 helix-turn-helix domain-containing protein -
JQU52_RS05700 (JQU52_05730) 1114423..1114653 + 231 WP_230340173.1 antitoxin MazE family protein Antitoxin
JQU52_RS05705 (JQU52_05735) 1114650..1114976 + 327 WP_230340174.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JQU52_RS05715 (JQU52_05745) 1115187..1115357 + 171 WP_230340175.1 hypothetical protein -
JQU52_RS05720 (JQU52_05750) 1115720..1116517 - 798 WP_230340176.1 hypothetical protein -
JQU52_RS05725 (JQU52_05755) 1116517..1116741 - 225 WP_230340177.1 hypothetical protein -
JQU52_RS05730 (JQU52_05760) 1116849..1117532 + 684 WP_230340178.1 S24 family peptidase -
JQU52_RS05740 (JQU52_05770) 1118647..1118817 + 171 WP_230340179.1 hypothetical protein -
JQU52_RS05745 (JQU52_05775) 1119178..1119786 - 609 WP_230340180.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1062617..1127893 65276


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-103)

Antitoxin

Antitoxin MazE-like

(7-68)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11612.73 Da        Isoelectric Point: 8.0340

>T191800 WP_230340174.1 NZ_CP069798:1114650-1114976 [Paralysiella testudinis]
MKRGDLITVAIQGDYGKPRPALVVQSDVFAGHTSICILPLTSDLHEAPLFRILLTPSSSNGLTKKSQVMVDKIMTIPIAK
AGEVIGSLDYTAMLEIDRSMALFLGIAK

Download         Length: 327 bp

>T191800 NZ_CP091913:2097664-2098065 [Nostoc sp. UHCC 0870]
ATGCGATATCTGCTTGATACCAATATCTGTATTTACCTCATCAAGCATAAACCTCAAAAAGTGTTAGATAAATTCCAAAC
CTTAAGCCTTTCTGATGTGGGTATTTCTTCCATTACTGTTGCTGAACTCGAATATGGAGTTGCCAAAAGTCAACAACAAA
ATAAAAATCGCACCGCCTTGCTACAATTTTTGCTACCTCTAGAAATTGTTGAATTCAATCAAGCATCTGCGACGATTTAC
GGCAGCATTAGAAGTGATCTCGAAAGTAGAGGACTTATCATTGGTGCAATGGATCTACTCATCGCTGCTCATACTCTCAG
TTTAGGAGTTACTCTCGTCACCAATAATACGCGAGAATTTGCTCGCATTCCCACACTGTTATTAGAGAATTGGGTTGAGT
AG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8492.66 Da        Isoelectric Point: 7.3207

>AT191800 WP_230340173.1 NZ_CP069798:1114423-1114653 [Paralysiella testudinis]
MMSNSASRVQQHRVRLRHAGLRPIQIWVPDTRRPGFAAEAHRQIALVAQGDRGDAQLAVMMDEALMNLADSGEWEA

Download         Length: 231 bp

>AT191800 NZ_CP091913:2097436-2097663 [Nostoc sp. UHCC 0870]
ATGAACATCGCCAAACTCAGCACTGATGGCACTCACCAATTTGTGATTTTGCCGGAAGATTTTCAACTCACTGGCACAGA
AGTTTATATTAAAAAAATTGGTAATGCAATTGTTCTCATTGCCAAAGATAATCCTTGGGAATCACTCATCGAGAGTTTAG
ACAATTTCTCCGATGATTTCATGACTACTAGAGATCAGCCACCAATCGATACCAGAGAGAGTTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References