Detailed information of TA system TA191795

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-YefM
• Location: 2062028..2062743
• Replicon: chromosome
• Accession: NZ_CP069797
• Organism: Actinobacillus pleuropneumoniae strain K17

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D1098_RS09740
• Protein ID: WP_005599445.1
• Coordinates: 2062028..2062393 (-)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B0BT01
• Locus tag: D1098_RS09745
• Protein ID: WP_005599447.1
• Coordinates: 2062456..2062743 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1098_RS09725 (D1098_09755)	2057613..2059319	-	1707	WP_005609259.1	bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase	-
D1098_RS09730 (D1098_09760)	2059415..2059696	-	282	WP_005599441.1	DNA-directed RNA polymerase subunit omega	-
D1098_RS09735 (D1098_09765)	2059823..2061904	-	2082	WP_009875323.1	ATP-dependent DNA helicase RecG	-
D1098_RS09740 (D1098_09770)	2062028..2062393	-	366	WP_005599445.1	type II toxin-antitoxin system VapC family toxin	Toxin
D1098_RS09745 (D1098_09775)	2062456..2062743	-	288	WP_005599447.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
D1098_RS09750 (D1098_09780)	2062949..2064664	+	1716	WP_009875324.1	proline--tRNA ligase	-
D1098_RS09755 (D1098_09785)	2064730..2064918	-	189	WP_005602684.1	hypothetical protein	-
D1098_RS09760 (D1098_09790)	2064921..2065502	-	582	WP_009875325.1	sigma-70 family RNA polymerase sigma factor	-
D1098_RS09765 (D1098_09795)	2065591..2066547	+	957	WP_005619040.1	protein-methionine-sulfoxide reductase catalytic subunit MsrP	-
D1098_RS09770 (D1098_09800)	2066547..2067140	+	594	WP_005599453.1	protein-methionine-sulfoxide reductase heme-binding subunit MsrQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-109)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 13974.06 Da
• Isoelectric Point: 9.0549

>T191795 WP_005599445.1 NZ_CP069797:c2062393-2062028 [Actinobacillus pleuropneumoniae]
MDTNVRQWLATIKPSQTNISCITLSEIKTGILLKARKDPIQAERLNHWFTHNVLSVYQAKSFSINNEIALLASEYHIPNK
MDLNDAYIAATAKYHNLVLVTRNLKDFNRCDIRLFNPFEPN

Nucleotide

• Length: 366 bp

>T191795 NZ_CP091906:2649062-2649205 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 11040.29 Da
• Isoelectric Point: 4.5578

>AT191795 WP_005599447.1 NZ_CP069797:c2062743-2062456 [Actinobacillus pleuropneumoniae]
MPITITSREFNQHASKVLKMAEKEPVFITKWGKIVSVVSNYVDYKQHTTVEPSFEELFASSTDESVSDEFWQDFEQTLTK
IRKSNKSEQIDFGDE

Nucleotide

• Length: 288 bp

>AT191795 NZ_CP091906:c2649399-2649137 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTATA
ATAGCATTGAAAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Antitoxin

• AlphaFold DB: A3N3C5