Detailed information of TA system TA191794

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1978149..1978777
• Replicon: chromosome
• Accession: NZ_CP069797
• Organism: Actinobacillus pleuropneumoniae strain K17

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D1098_RS09220
• Protein ID: WP_009875032.1
• Coordinates: 1978379..1978777 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B3GYV7
• Locus tag: D1098_RS09215
• Protein ID: WP_005613300.1
• Coordinates: 1978149..1978379 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1098_RS09210 (D1098_09240)	1975996..1977627	+	1632	WP_042655123.1	hypothetical protein	-
D1098_RS09215 (D1098_09245)	1978149..1978379	+	231	WP_005613300.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
D1098_RS09220 (D1098_09250)	1978379..1978777	+	399	WP_009875032.1	tRNA(fMet)-specific endonuclease VapC	Toxin
D1098_RS09225 (D1098_09255)	1978912..1979328	-	417	WP_005618204.1	DUF417 family protein	-
D1098_RS09230 (D1098_09260)	1979574..1980224	+	651	WP_005618207.1	DUF2202 domain-containing protein	-
D1098_RS09235 (D1098_09265)	1980404..1981183	-	780	WP_005602546.1	hypothetical protein	-
D1098_RS09240 (D1098_09270)	1981256..1982578	-	1323	WP_005620148.1	HslU--HslV peptidase ATPase subunit	-
D1098_RS09245 (D1098_09275)	1982633..1983154	-	522	WP_005618211.1	ATP-dependent protease subunit HslV	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1962633..1981183	18550

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (6-53)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15105.39 Da
• Isoelectric Point: 7.4195

>T191794 WP_009875032.1 NZ_CP069797:1978379-1978777 [Actinobacillus pleuropneumoniae]
MLTYMLDTNIAIYVIKRRPIEVLDKFNLNSTRLCISSITAAELYYGAEKSQFPERNMAVIEDFLSRLTILDYTHKAATHF
GNIKAHLSKQGKIIGENDIHIAAHARSEGLVLVTNNLREFERVEGLRLDNWV

Nucleotide

• Length: 399 bp

>T191794 NZ_CP091906:2649062-2649205 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8625.71 Da
• Isoelectric Point: 4.5358

>AT191794 WP_005613300.1 NZ_CP069797:1978149-1978379 [Actinobacillus pleuropneumoniae]
MEASVFMTNRSQAVRLPAEVRFASDVKKLSVRVVGNERILAPINQSWDSFFLSSATVSDDFMTEREISTQAEREEL

Nucleotide

• Length: 231 bp

>AT191794 NZ_CP091906:c2648951-2648818 [Enterococcus faecalis]
TTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCCGT
TATTATTTAAAAATAACCGTACTTGGTCAAAGTAGACGGTTATTTTTTCTTGTC

Structures

Antitoxin

• AlphaFold DB: A3N328