Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VagC |
| Location | 1978149..1978777 | Replicon | chromosome |
| Accession | NZ_CP069797 | ||
| Organism | Actinobacillus pleuropneumoniae strain K17 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | D1098_RS09220 | Protein ID | WP_009875032.1 |
| Coordinates | 1978379..1978777 (+) | Length | 133 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | B3GYV7 |
| Locus tag | D1098_RS09215 | Protein ID | WP_005613300.1 |
| Coordinates | 1978149..1978379 (+) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| D1098_RS09210 (D1098_09240) | 1975996..1977627 | + | 1632 | WP_042655123.1 | hypothetical protein | - |
| D1098_RS09215 (D1098_09245) | 1978149..1978379 | + | 231 | WP_005613300.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| D1098_RS09220 (D1098_09250) | 1978379..1978777 | + | 399 | WP_009875032.1 | tRNA(fMet)-specific endonuclease VapC | Toxin |
| D1098_RS09225 (D1098_09255) | 1978912..1979328 | - | 417 | WP_005618204.1 | DUF417 family protein | - |
| D1098_RS09230 (D1098_09260) | 1979574..1980224 | + | 651 | WP_005618207.1 | DUF2202 domain-containing protein | - |
| D1098_RS09235 (D1098_09265) | 1980404..1981183 | - | 780 | WP_005602546.1 | hypothetical protein | - |
| D1098_RS09240 (D1098_09270) | 1981256..1982578 | - | 1323 | WP_005620148.1 | HslU--HslV peptidase ATPase subunit | - |
| D1098_RS09245 (D1098_09275) | 1982633..1983154 | - | 522 | WP_005618211.1 | ATP-dependent protease subunit HslV | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1962633..1981183 | 18550 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 15105.39 Da Isoelectric Point: 7.4195
>T191794 WP_009875032.1 NZ_CP069797:1978379-1978777 [Actinobacillus pleuropneumoniae]
MLTYMLDTNIAIYVIKRRPIEVLDKFNLNSTRLCISSITAAELYYGAEKSQFPERNMAVIEDFLSRLTILDYTHKAATHF
GNIKAHLSKQGKIIGENDIHIAAHARSEGLVLVTNNLREFERVEGLRLDNWV
MLTYMLDTNIAIYVIKRRPIEVLDKFNLNSTRLCISSITAAELYYGAEKSQFPERNMAVIEDFLSRLTILDYTHKAATHF
GNIKAHLSKQGKIIGENDIHIAAHARSEGLVLVTNNLREFERVEGLRLDNWV
Download Length: 399 bp
>T191794 NZ_CP091906:2649062-2649205 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8625.71 Da Isoelectric Point: 4.5358
>AT191794 WP_005613300.1 NZ_CP069797:1978149-1978379 [Actinobacillus pleuropneumoniae]
MEASVFMTNRSQAVRLPAEVRFASDVKKLSVRVVGNERILAPINQSWDSFFLSSATVSDDFMTEREISTQAEREEL
MEASVFMTNRSQAVRLPAEVRFASDVKKLSVRVVGNERILAPINQSWDSFFLSSATVSDDFMTEREISTQAEREEL
Download Length: 231 bp
>AT191794 NZ_CP091906:c2648951-2648818 [Enterococcus faecalis]
TTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCCGT
TATTATTTAAAAATAACCGTACTTGGTCAAAGTAGACGGTTATTTTTTCTTGTC
TTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCCGT
TATTATTTAAAAATAACCGTACTTGGTCAAAGTAGACGGTTATTTTTTCTTGTC
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|