Detailed information of TA system TA191793

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1915456..1917113
• Replicon: chromosome
• Accession: NZ_CP069797
• Organism: Actinobacillus pleuropneumoniae strain K17

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A3N2X8
• Locus tag: D1098_RS08950
• Protein ID: WP_011848633.1
• Coordinates: 1915782..1917113 (-)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A3N2X7
• Locus tag: D1098_RS08945
• Protein ID: WP_005613259.1
• Coordinates: 1915456..1915785 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1098_RS08925 (D1098_08955)	1912786..1913403	+	618	WP_009874973.1	dimethylsulfoxide reductase subunit B	-
D1098_RS08930 (D1098_08960)	1913405..1914238	+	834	WP_009874972.1	dimethyl sulfoxide reductase anchor subunit	-
D1098_RS08935 (D1098_08965)	1914294..1914899	+	606	WP_009874971.1	Tat proofreading chaperone DmsD	-
D1098_RS08940 (D1098_08970)	1914903..1915412	+	510	WP_009874970.1	ferredoxin-type protein NapF	-
D1098_RS08945 (D1098_08975)	1915456..1915785	-	330	WP_005613259.1	helix-turn-helix domain-containing protein	Antitoxin
D1098_RS08950 (D1098_08980)	1915782..1917113	-	1332	WP_011848633.1	HipA domain-containing protein	Toxin
D1098_RS08955 (D1098_08985)	1917445..1919136	-	1692	WP_042655118.1	AIPR family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (164-371)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-94)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51131.07 Da
• Isoelectric Point: 5.0347

>T191793 WP_011848633.1 NZ_CP069797:c1917113-1915782 [Actinobacillus pleuropneumoniae]
MSDISVKNKKLTLQTYVDNLWRDMAELYFNAQYELESMEYLTDYAVDFFGQANARSISINYPVNVFIDHADKLMTTLADI
IPAGASRRYWLEALDIKHLSISHQNYLLLKNGAISPIGNVRVKEAVPEIQSERYFPLNVVQNRQSDFLEYANQTGAMVGG
ATGAGGEAPKLLLKCQDKQVWIDNLQLGLDCDTAYLVKYPRGNYSELDCDILRAEYHYYHELRALGFSTIDTDLMKLEEG
ERYPSLWLPRFDMKFKDGKWERYAMESVYSMLQKYGGNLDHEQTIRNLLNIISASQFSNDFDNRHFVIEWVKRDLLNIAF
GNSDNHGRNTAFLRDDNRIWLSPIYDFAPMRADPEGIIRTTTWAKNGDNPQEFAGEYRFDKIADGLSDLIEPDILLRELR
MLATQLVDLKSRLMKRGVPKSILDFPAIGFDYLPEKLQRWGLV

Nucleotide

• Length: 1332 bp

>T191793 NZ_CP091906:2644394-2644498 [Enterococcus faecalis]
TTGTCAGCATATGAGACAATTCAGACGATTCTAGGTTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATT
GCTTAAAAATGACAAGAAAAAATAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12320.45 Da
• Isoelectric Point: 10.8292

>AT191793 WP_005613259.1 NZ_CP069797:c1915785-1915456 [Actinobacillus pleuropneumoniae]
MTIQHKNASPTRSKVNGIERQLIRETIIVQLLKGEISQGQALRRLRVEALGINQQDYLKLAKVSRQTLSNIENDKGNYSI
ETINQVFKPMGLKLGLMPISKDLMASFLK

Nucleotide

• Length: 330 bp

>AT191793 NZ_CP091906:c2644686-2644431 [Enterococcus faecalis]
ATAAAAATGCCCGAGCCTTGAAATAGGAGGCTCAGGCATTTTTTATTGATGGTCTTTTTAGGGTTGTTGTGCTATAATGA
TAAAGAAAAGAGAGATATGCTTCCAACATATCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGTGTTAATTATTTAAA
AATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCAATCAAAGCA
ATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A3N2X8

Antitoxin

• AlphaFold DB: A3N2X7