Detailed information of TA system TA191792

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1763209..1763940
• Replicon: chromosome
• Accession: NZ_CP069797
• Organism: Actinobacillus pleuropneumoniae strain K17

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: A3N2I6
• Locus tag: D1098_RS08165
• Protein ID: WP_009875245.1
• Coordinates: 1763209..1763676 (-)
• Length: 156 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: B0BRD3
• Locus tag: D1098_RS08170
• Protein ID: WP_005619269.1
• Coordinates: 1763680..1763940 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1098_RS08140 (D1098_08165)	1758567..1758938	-	372	WP_005598830.1	CrcB family protein	-
D1098_RS08145 (D1098_08170)	1758941..1760005	-	1065	WP_011848610.1	MFS transporter	-
D1098_RS08150 (D1098_08175)	1760100..1761209	+	1110	WP_009875243.1	anhydro-N-acetylmuramic acid kinase	-
D1098_RS08155 (D1098_08180)	1761263..1762177	+	915	WP_009875244.1	N-acetylmuramic acid 6-phosphate etherase	-
D1098_RS08160 (D1098_08185)	1762244..1763125	-	882	WP_005608878.1	50S ribosomal protein L11 methyltransferase	-
D1098_RS08165 (D1098_08190)	1763209..1763676	-	468	WP_009875245.1	GNAT family N-acetyltransferase	Toxin
D1098_RS08170 (D1098_08195)	1763680..1763940	-	261	WP_005619269.1	DUF1778 domain-containing protein	Antitoxin
D1098_RS08175 (D1098_08200)	1764061..1765521	-	1461	WP_009875246.1	metalloprotease TldD	-
D1098_RS08180 (D1098_08205)	1765651..1766910	+	1260	WP_005608887.1	tRNA lysidine(34) synthetase TilS	-
D1098_RS08185 (D1098_08210)	1766937..1767149	-	213	WP_237593654.1	DUF5389 family protein	-
D1098_RS08190 (D1098_08215)	1767229..1768122	-	894	WP_005598850.1	site-specific tyrosine recombinase XerD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (40-142)

Antitoxin

• Vibrio phage ICP1, Orf50 (6-80)

Sequences

Toxin

Protein

• Length: 156 a.a.
• Molecular weight: 17227.20 Da
• Isoelectric Point: 9.5125

>T191792 WP_009875245.1 NZ_CP069797:c1763676-1763209 [Actinobacillus pleuropneumoniae]
MHAPELLSEQHIVRYFQCGEVVLDQWLQRTALKNQQNNASKTFVVRDENKQVMGFYCLSAGSVSHQFVAGALRRNMPDPI
PVIILGRLAVDCSAQGKQLGVSMLKDAVLKSKTVANQIGVKALLVHALNPQAKQFYLKYGFSCSPIDEIVLMLKL

Nucleotide

• Length: 468 bp

>T191792 NZ_CP091906:c2638998-2638657 [Enterococcus faecalis]
ATGAACGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGTAAAGAAAT
TCAGAAGAGACGCCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
CTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACATAGAAACCCATGGGCAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9796.14 Da
• Isoelectric Point: 4.4883

>AT191792 WP_005619269.1 NZ_CP069797:c1763940-1763680 [Actinobacillus pleuropneumoniae]
MRTAPINLRAMPDQRDLIDYAASILGKTRSDFMLETACQAAQNVILDRTVFQLNEQAFEQFNRLLEQPTADNPGLDKLLN
TKAVWE

Nucleotide

• Length: 261 bp

>AT191792 NZ_CP091906:c2639228-2638998 [Enterococcus faecalis]
ATGCTAACAACTAAATCAAGAAGACAAGGAAACTCGGTCGTTTTAACTTTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGATGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GTCCAGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA

Structures

Toxin

• AlphaFold DB: A3N2I6

Antitoxin

• AlphaFold DB: A3N2I7