Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-MazE |
| Location | 884332..884982 | Replicon | chromosome |
| Accession | NZ_CP069797 | ||
| Organism | Actinobacillus pleuropneumoniae strain K17 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | B0BNU3 |
| Locus tag | D1098_RS04070 | Protein ID | WP_005614926.1 |
| Coordinates | 884593..884982 (+) | Length | 130 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | B0BNU4 |
| Locus tag | D1098_RS04065 | Protein ID | WP_005604117.1 |
| Coordinates | 884332..884592 (+) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| D1098_RS04045 (D1098_04065) | 879352..879972 | - | 621 | WP_009874703.1 | hypothetical protein | - |
| D1098_RS04050 (D1098_04070) | 879983..881176 | - | 1194 | WP_009874702.1 | iron uptake transporter deferrochelatase/peroxidase subunit | - |
| D1098_RS04055 (D1098_04075) | 881188..882000 | - | 813 | WP_005607533.1 | iron uptake system protein EfeO | - |
| D1098_RS04060 (D1098_04080) | 882177..884198 | + | 2022 | WP_009874701.1 | excinuclease ABC subunit UvrB | - |
| D1098_RS04065 (D1098_04085) | 884332..884592 | + | 261 | WP_005604117.1 | hypothetical protein | Antitoxin |
| D1098_RS04070 (D1098_04090) | 884593..884982 | + | 390 | WP_005614926.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| D1098_RS04075 (D1098_04095) | 885118..886341 | + | 1224 | WP_009874700.1 | ATP-binding protein | - |
| D1098_RS04080 (D1098_04100) | 886750..888036 | + | 1287 | WP_009874699.1 | Xaa-Pro aminopeptidase | - |
| D1098_RS04085 (D1098_04105) | 888215..889411 | - | 1197 | WP_009874698.1 | amino acid aminotransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 130 a.a. Molecular weight: 14837.17 Da Isoelectric Point: 5.1295
>T191791 WP_005614926.1 NZ_CP069797:884593-884982 [Actinobacillus pleuropneumoniae]
MYMLDTNTVSYFFRQDPTVVKKLQQLNPELICISSVTAAELFYGVKKRNNQKLTAFLNTFLSAITVMDWDYQVAEVYGQL
RAEMEREGKIMGVQDQMIGAHALATECVLVSSDKAFQFIPNLVLENWWK
MYMLDTNTVSYFFRQDPTVVKKLQQLNPELICISSVTAAELFYGVKKRNNQKLTAFLNTFLSAITVMDWDYQVAEVYGQL
RAEMEREGKIMGVQDQMIGAHALATECVLVSSDKAFQFIPNLVLENWWK
Download Length: 390 bp
>T191791 NZ_CP091906:c2566134-2565991 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 10289.63 Da Isoelectric Point: 5.1867
>AT191791 WP_005604117.1 NZ_CP069797:884332-884592 [Actinobacillus pleuropneumoniae]
MEKVARLFRNGRNQAVRLPVEFEFNAKQVYVFKEANGDITLSTRSRNQQNWQKVFELLPMLECDEQFLSEQERKQEMATR
DPFEGF
MEKVARLFRNGRNQAVRLPVEFEFNAKQVYVFKEANGDITLSTRSRNQQNWQKVFELLPMLECDEQFLSEQERKQEMATR
DPFEGF
Download Length: 261 bp
>AT191791 NZ_CP091906:2565872-2566058 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGCG
CAATCAAAGCAATGGTAAACATACCAA
TGTGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGCG
CAATCAAAGCAATGGTAAACATACCAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|