Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 175977..176485 Replicon chromosome
Accession NZ_CP069797
Organism Actinobacillus pleuropneumoniae strain K17

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag D1098_RS00890 Protein ID WP_009875288.1
Coordinates 175977..176237 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A3N1S6
Locus tag D1098_RS00895 Protein ID WP_005605062.1
Coordinates 176234..176485 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1098_RS00850 (D1098_00855) 171082..171855 + 774 WP_009875285.1 DNA polymerase III subunit epsilon -
D1098_RS00865 (D1098_00870) 172214..172606 - 393 WP_005620423.1 SufE family protein -
D1098_RS00870 (D1098_00875) 172728..173318 + 591 WP_005598326.1 ATP-dependent Clp endopeptidase proteolytic subunit ClpP -
D1098_RS00875 (D1098_00880) 173318..174577 + 1260 WP_005598324.1 ATP-dependent protease ATP-binding subunit ClpX -
D1098_RS00880 (D1098_00885) 174671..175651 + 981 WP_005608502.1 tetraacyldisaccharide 4'-kinase -
D1098_RS00885 (D1098_00890) 175653..175820 + 168 WP_009875287.1 Trm112 family protein -
D1098_RS00890 (D1098_00895) 175977..176237 - 261 WP_009875288.1 Txe/YoeB family addiction module toxin Toxin
D1098_RS00895 (D1098_00900) 176234..176485 - 252 WP_005605062.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
D1098_RS00905 (D1098_00910) 176822..178261 - 1440 WP_009875289.1 glutamate--tRNA ligase -
D1098_RS00930 (D1098_00935) 179165..180346 + 1182 WP_009875290.1 bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN -
D1098_RS00935 (D1098_00940) 180400..180948 + 549 WP_011848557.1 type IV pilus biogenesis/stability protein PilW -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10452.00 Da        Isoelectric Point: 8.0109

>T191790 WP_009875288.1 NZ_CP069797:c176237-175977 [Actinobacillus pleuropneumoniae]
MKLTFSSNAWEDYLYWQKTDKIILKRINSLIKDIQRQPFEGIGKPEPLKFNLSGFWSRRINEEHRLIYTVEDETILIVAC
RYHYDQ

Download         Length: 261 bp

>T191790 NZ_CP091906:c2494156-2494055 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9320.62 Da        Isoelectric Point: 4.5659

>AT191790 WP_005605062.1 NZ_CP069797:c176485-176234 [Actinobacillus pleuropneumoniae]
MQAITYTEARQNLAGTMSKVAEDFEPILITRSKGGNCVLMSYEQYSSLEETAYLMRSPANAQRLLDSMAELKQGKGIERE
LIE

Download         Length: 252 bp

>AT191790 NZ_CP091906:2493931-2494110 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A3N1S6

References