Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 89760..90405 Replicon chromosome
Accession NZ_CP069797
Organism Actinobacillus pleuropneumoniae strain K17

Toxin (Protein)


Gene name toxT Uniprot ID B0BQU7
Locus tag D1098_RS00435 Protein ID WP_005619674.1
Coordinates 89760..90131 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag D1098_RS00440 Protein ID WP_005598477.1
Coordinates 90112..90405 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1098_RS00420 (D1098_00420) 86290..87144 + 855 WP_009874917.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
D1098_RS00425 (D1098_00425) 87188..87757 - 570 WP_005601959.1 elongation factor P hydroxylase -
D1098_RS00430 (D1098_00430) 87815..89566 - 1752 WP_005601957.1 protein-disulfide reductase DsbD -
D1098_RS00435 (D1098_00435) 89760..90131 + 372 WP_005619674.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D1098_RS00440 (D1098_00440) 90112..90405 + 294 WP_005598477.1 helix-turn-helix domain-containing protein Antitoxin
D1098_RS00445 (D1098_00445) 90483..91445 - 963 WP_005619672.1 calcium/sodium antiporter -
D1098_RS00450 (D1098_00450) 91518..92015 + 498 WP_005601953.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
D1098_RS00455 (D1098_00455) 92240..92974 + 735 WP_005612838.1 arginine ABC transporter ATP-binding protein ArtP -
D1098_RS00460 (D1098_00460) 92994..93713 + 720 WP_011848574.1 transporter substrate-binding domain-containing protein -
D1098_RS00465 (D1098_00465) 93719..94390 + 672 WP_011848573.1 arginine ABC transporter permease ArtQ -
D1098_RS00470 (D1098_00470) 94390..95073 + 684 WP_005605188.1 arginine ABC transporter permease ArtM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(32-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 15066.57 Da        Isoelectric Point: 10.4054

>T191789 WP_005619674.1 NZ_CP069797:89760-90131 [Actinobacillus pleuropneumoniae]
MYEIVFYRDKRGREPVKEFLLRLLKERQEGSRERLHKISHHLSILHLHGTRAGENYIKHLEDRIWQLRPVGDCLLFASII
RGKFVLLHYFAKQNYRIPKREIERAKVRLADLQERIKDEPYWF

Download         Length: 372 bp

>T191789 NZ_CP091906:c2493723-2493622 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCATTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10935.81 Da        Isoelectric Point: 10.3120

>AT191789 WP_005598477.1 NZ_CP069797:90112-90405 [Actinobacillus pleuropneumoniae]
MSPIGSSWTSFEQEIFDESEIAETQFRIRLILEIIETRQQLGISQRKLEKLSGVKQSMIARVEKGSVNPSLATVLKLLVP
LGKTLQIVPLDKNKTVR

Download         Length: 294 bp

>AT191789 NZ_CP091906:2493500-2493677 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAGCGCCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTT
TTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGA
AAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A3N206

Antitoxin

Source ID Structure

References