Detailed information of TA system TA191788

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1988003..1988631
• Replicon: chromosome
• Accession: NZ_CP069796
• Organism: Actinobacillus pleuropneumoniae serovar 6 str. Femo

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D1099_RS09610
• Protein ID: WP_005609156.1
• Coordinates: 1988003..1988401 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A828PGB0
• Locus tag: D1099_RS09615
• Protein ID: WP_005599241.1
• Coordinates: 1988401..1988631 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1099_RS09585 (D1099_09560)	1983649..1984170	+	522	WP_005605772.1	ATP-dependent protease subunit HslV	-
D1099_RS09590 (D1099_09565)	1984225..1985547	+	1323	WP_005620148.1	HslU--HslV peptidase ATPase subunit	-
D1099_RS09595	1985861..1986091	+	231	WP_237611500.1	hypothetical protein	-
D1099_RS09600 (D1099_09575)	1986555..1987205	-	651	WP_005609160.1	DUF2202 domain-containing protein	-
D1099_RS09605 (D1099_09580)	1987452..1987868	+	417	WP_005609158.1	DUF417 family protein	-
D1099_RS09610 (D1099_09585)	1988003..1988401	-	399	WP_005609156.1	tRNA(fMet)-specific endonuclease VapC	Toxin
D1099_RS09615 (D1099_09590)	1988401..1988631	-	231	WP_005599241.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
D1099_RS09620 (D1099_09595)	1988739..1988879	+	141	WP_005609154.1	hypothetical protein	-
D1099_RS09625 (D1099_09600)	1989255..1989827	-	573	WP_005620147.1	hypothetical protein	-
D1099_RS09630 (D1099_09605)	1989820..1991235	-	1416	WP_005605761.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1973271..2003854	30583

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (6-52)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15066.37 Da
• Isoelectric Point: 7.3824

>T191788 WP_005609156.1 NZ_CP069796:c1988401-1988003 [Actinobacillus pleuropneumoniae serovar 6 str. Femo]
MLTYMLDTNIAIYVIKRRPIEVLDKFNLNSTRLCVSSITAAELYYGAEKSQFPERNMAVIEDFLSRLTILDYTHKAATHF
GNIKAHLSKCGKILGENDIHIAAHARSEGLVLVTNNLREFERVEGLRLDNWV

Nucleotide

• Length: 399 bp

>T191788 NZ_CP091906:514691-514801 [Enterococcus faecalis]
TTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTTAGCGCT
TGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8561.71 Da
• Isoelectric Point: 4.7063

>AT191788 WP_005599241.1 NZ_CP069796:c1988631-1988401 [Actinobacillus pleuropneumoniae serovar 6 str. Femo]
MEASVFMTNRSQAVRLPAEVRFASDVKKLSVRVVGNERILAPINQSWDSFFLGSATVSDDFMTEREISIQPEREGL

Nucleotide

• Length: 231 bp

>AT191788 NZ_CP091906:c514917-514712 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAGTAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Structures

Antitoxin

• AlphaFold DB: A0A828PGB0