Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-YefM
Location 1893677..1894392 Replicon chromosome
Accession NZ_CP069796
Organism Actinobacillus pleuropneumoniae serovar 6 str. Femo

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag D1099_RS09035 Protein ID WP_005606490.1
Coordinates 1894027..1894392 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B0BT01
Locus tag D1099_RS09030 Protein ID WP_005599447.1
Coordinates 1893677..1893964 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1099_RS09005 (D1099_08985) 1889279..1889872 - 594 WP_005599453.1 protein-methionine-sulfoxide reductase heme-binding subunit MsrQ -
D1099_RS09010 (D1099_08990) 1889872..1890828 - 957 WP_005619040.1 protein-methionine-sulfoxide reductase catalytic subunit MsrP -
D1099_RS09015 (D1099_08995) 1890918..1891499 + 582 WP_005609269.1 sigma-70 family RNA polymerase sigma factor -
D1099_RS09020 (D1099_09000) 1891502..1891690 + 189 WP_005602684.1 hypothetical protein -
D1099_RS09025 (D1099_09005) 1891756..1893471 - 1716 WP_005609267.1 proline--tRNA ligase -
D1099_RS09030 (D1099_09010) 1893677..1893964 + 288 WP_005599447.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
D1099_RS09035 (D1099_09015) 1894027..1894392 + 366 WP_005606490.1 type II toxin-antitoxin system VapC family toxin Toxin
D1099_RS09040 (D1099_09020) 1894516..1896597 + 2082 WP_005609262.1 ATP-dependent DNA helicase RecG -
D1099_RS09045 (D1099_09025) 1896724..1897005 + 282 WP_005609261.1 DNA-directed RNA polymerase subunit omega -
D1099_RS09050 (D1099_09030) 1897101..1898807 + 1707 WP_005609259.1 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13921.01 Da        Isoelectric Point: 8.2783

>T191787 WP_005606490.1 NZ_CP069796:1894027-1894392 [Actinobacillus pleuropneumoniae serovar 6 str. Femo]
MDTNVRQWLATIKPSQTNISCITLSEIKTGILLKARKDPIQAERLNHWFTHNVLSVYQAKSFSINNEIALLASEYHIPNK
MDLNDAYIAATAKYHNLVLVTRNLKDFNCCDIRLFNPFEPN

Download         Length: 366 bp

>T191787 NZ_CP091906:c309509-309414 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCTATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11040.29 Da        Isoelectric Point: 4.5578

>AT191787 WP_005599447.1 NZ_CP069796:1893677-1893964 [Actinobacillus pleuropneumoniae serovar 6 str. Femo]
MPITITSREFNQHASKVLKMAEKEPVFITKWGKIVSVVSNYVDYKQHTTVEPSFEELFASSTDESVSDEFWQDFEQTLTK
IRKSNKSEQIDFGDE

Download         Length: 288 bp

>AT191787 NZ_CP091906:309314-309379 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATCAGTAGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A3N3C5

References