Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1870071..1870802 Replicon chromosome
Accession NZ_CP069796
Organism Actinobacillus pleuropneumoniae serovar 6 str. Femo

Toxin (Protein)


Gene name tacT Uniprot ID A0A828PH43
Locus tag D1099_RS08885 Protein ID WP_005608881.1
Coordinates 1870071..1870538 (-) Length 156 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID B0BRD3
Locus tag D1099_RS08890 Protein ID WP_005619269.1
Coordinates 1870542..1870802 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1099_RS08860 (D1099_08840) 1865428..1865799 - 372 WP_005598830.1 CrcB family protein -
D1099_RS08865 (D1099_08845) 1865802..1866866 - 1065 WP_005602204.1 MFS transporter -
D1099_RS08870 (D1099_08850) 1866961..1868070 + 1110 WP_005608870.1 anhydro-N-acetylmuramic acid kinase -
D1099_RS08875 (D1099_08855) 1868123..1869037 + 915 WP_005608875.1 N-acetylmuramic acid 6-phosphate etherase -
D1099_RS08880 (D1099_08860) 1869107..1869988 - 882 WP_005608878.1 50S ribosomal protein L11 methyltransferase -
D1099_RS08885 (D1099_08865) 1870071..1870538 - 468 WP_005608881.1 GNAT family N-acetyltransferase Toxin
D1099_RS08890 (D1099_08870) 1870542..1870802 - 261 WP_005619269.1 DUF1778 domain-containing protein Antitoxin
D1099_RS08895 (D1099_08875) 1870923..1872383 - 1461 WP_005608884.1 metalloprotease TldD -
D1099_RS08900 (D1099_08880) 1872513..1873772 + 1260 WP_005608887.1 tRNA lysidine(34) synthetase TilS -
D1099_RS08905 (D1099_08885) 1873799..1874089 - 291 WP_005608889.1 DUF5389 family protein -
D1099_RS08910 (D1099_08890) 1874091..1874984 - 894 WP_005608892.1 site-specific tyrosine recombinase XerD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(40-142)

Antitoxin

Vibrio phage ICP1, Orf50

(6-80)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 17259.26 Da        Isoelectric Point: 9.5125

>T191786 WP_005608881.1 NZ_CP069796:c1870538-1870071 [Actinobacillus pleuropneumoniae serovar 6 str. Femo]
MHAPELLSEQHIVRYFQCGEVVLDQWLQRTALKNQQNNASKTFVVRDENKQVMGFYCLSAGSVSHQFVAGALRRNMPDPI
PVIILGRLAVDCSAQGKQLGVSMLKDAVLKSKTVANQIGIKALLVHALNPQAKQFYLKYGFSCSPIDEMVLMLKL

Download         Length: 468 bp

>T191786 NZ_CP091905:52435-52545 [Enterococcus faecalis]
GTGTTATTTGTGAAAGATTTAATGTCGTTGGTTATCGCACCGATCTTTGTAGGATTGGTTCTGGAAATGATTTCTCGTGT
GTTGGACGAGGAAGACGATAACCGAAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9796.14 Da        Isoelectric Point: 4.4883

>AT191786 WP_005619269.1 NZ_CP069796:c1870802-1870542 [Actinobacillus pleuropneumoniae serovar 6 str. Femo]
MRTAPINLRAMPDQRDLIDYAASILGKTRSDFMLETACQAAQNVILDRTVFQLNEQAFEQFNRLLEQPTADNPGLDKLLN
TKAVWE

Download         Length: 261 bp

>AT191786 NZ_CP091905:c52649-52585 [Enterococcus faecalis]
AACGACATTAAATCGTACAAATAACACAAAAAGCAATCCTACGGCGAATAGGATTGCTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828PH43

Antitoxin

Source ID Structure
AlphaFold DB A3N2I7

References