Detailed information of TA system TA191785

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 1665078..1665723
• Replicon: chromosome
• Accession: NZ_CP069796
• Organism: Actinobacillus pleuropneumoniae serovar 6 str. Femo

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: B0BQU7
• Locus tag: D1099_RS07880
• Protein ID: WP_005619674.1
• Coordinates: 1665352..1665723 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: D1099_RS07875
• Protein ID: WP_005598477.1
• Coordinates: 1665078..1665371 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1099_RS07845 (D1099_07825)	1660410..1661093	-	684	WP_005608586.1	arginine ABC transporter permease ArtM	-
D1099_RS07850 (D1099_07830)	1661093..1661764	-	672	WP_005608588.1	arginine ABC transporter permease ArtQ	-
D1099_RS07855 (D1099_07835)	1661770..1662489	-	720	WP_005619670.1	transporter substrate-binding domain-containing protein	-
D1099_RS07860 (D1099_07840)	1662509..1663243	-	735	WP_005598473.1	arginine ABC transporter ATP-binding protein ArtP	-
D1099_RS07865 (D1099_07845)	1663468..1663965	-	498	WP_005601953.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
D1099_RS07870 (D1099_07850)	1664038..1665000	+	963	WP_005608590.1	calcium/sodium antiporter	-
D1099_RS07875 (D1099_07855)	1665078..1665371	-	294	WP_005598477.1	helix-turn-helix domain-containing protein	Antitoxin
D1099_RS07880 (D1099_07860)	1665352..1665723	-	372	WP_005619674.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D1099_RS07885 (D1099_07865)	1665917..1667668	+	1752	WP_005608592.1	protein-disulfide reductase DsbD	-
D1099_RS07890 (D1099_07870)	1667726..1668295	+	570	WP_005608594.1	elongation factor P hydroxylase	-
D1099_RS07895 (D1099_07875)	1668339..1669193	-	855	WP_005608596.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (32-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-85)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 15066.57 Da
• Isoelectric Point: 10.4054

>T191785 WP_005619674.1 NZ_CP069796:c1665723-1665352 [Actinobacillus pleuropneumoniae serovar 6 str. Femo]
MYEIVFYRDKRGREPVKEFLLRLLKERQEGSRERLHKISHHLSILHLHGTRAGENYIKHLEDRIWQLRPVGDCLLFASII
RGKFVLLHYFAKQNYRIPKREIERAKVRLADLQERIKDEPYWF

Nucleotide

• Length: 372 bp

>T191785 NZ_CP091905:45333-45623 [Enterococcus faecalis]
ATGGCGAATATTACTGACTTCACCGAAAAGCAATTTGAAGATCGTTTAGAAAAGAATGTTGAACGACTAACTAAAAATAG
ACTAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCAAATTTTGACGAATTAGTG
AAACGGTTCTGTTGCAAAGTTTTAAATCTACTATCAAATAAGGTAGAATAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10935.81 Da
• Isoelectric Point: 10.3120

>AT191785 WP_005598477.1 NZ_CP069796:c1665371-1665078 [Actinobacillus pleuropneumoniae serovar 6 str. Femo]
MSPIGSSWTSFEQEIFDESEIAETQFRIRLILEIIETRQQLGISQRKLEKLSGVKQSMIARVEKGSVNPSLATVLKLLVP
LGKTLQIVPLDKNKTVR

Nucleotide

• Length: 294 bp

>AT191785 NZ_CP091905:45059-45331 [Enterococcus faecalis]
ATGGCAGTTACGTATGAAAAAACATTTGAAATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGGGTATTAAA
TTATGTTTTGAATCATGAACTAGATACTAAAAATACTCGTTTACTAGAAGTGAATCTTTTAAATCAATTAGAAGTGGCAC
AAGAAGTTGATTTATTTCAACAACCATTTGAAGAATTACAAGCTATTCATGAGTATTGGCGGTCAATGAATCAATATTCA
AAACAAATTTTGAATAAAGAGAAAGTGGCTTAA

Structures

Toxin

• AlphaFold DB: A3N206