Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 1571074..1571582 Replicon chromosome
Accession NZ_CP069796
Organism Actinobacillus pleuropneumoniae serovar 6 str. Femo

Toxin (Protein)


Gene name relE Uniprot ID B0BQK9
Locus tag D1099_RS07405 Protein ID WP_005605064.1
Coordinates 1571322..1571582 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B0BQK8
Locus tag D1099_RS07400 Protein ID WP_005598318.1
Coordinates 1571074..1571325 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1099_RS07360 (D1099_07340) 1566608..1567156 - 549 WP_005608494.1 type IV pilus biogenesis/stability protein PilW -
D1099_RS07365 (D1099_07345) 1567210..1568391 - 1182 WP_005608495.1 bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN -
D1099_RS07390 (D1099_07370) 1569297..1570736 + 1440 WP_005608501.1 glutamate--tRNA ligase -
D1099_RS07400 (D1099_07380) 1571074..1571325 + 252 WP_005598318.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
D1099_RS07405 (D1099_07385) 1571322..1571582 + 261 WP_005605064.1 Txe/YoeB family addiction module toxin Toxin
D1099_RS07410 (D1099_07390) 1571741..1571908 - 168 WP_005598320.1 Trm112 family protein -
D1099_RS07415 (D1099_07395) 1571910..1572890 - 981 WP_005608502.1 tetraacyldisaccharide 4'-kinase -
D1099_RS07420 (D1099_07400) 1572984..1574243 - 1260 WP_005598324.1 ATP-dependent protease ATP-binding subunit ClpX -
D1099_RS07425 (D1099_07405) 1574243..1574833 - 591 WP_005598326.1 ATP-dependent Clp endopeptidase proteolytic subunit ClpP -
D1099_RS07430 (D1099_07410) 1574955..1575347 + 393 WP_005620423.1 SufE family protein -
D1099_RS07445 (D1099_07425) 1575706..1576479 - 774 WP_005620420.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10423.99 Da        Isoelectric Point: 8.0109

>T191784 WP_005605064.1 NZ_CP069796:1571322-1571582 [Actinobacillus pleuropneumoniae serovar 6 str. Femo]
MKLTFSSNAWEDYLYWQKTDKIILKRINSLIKDIQRQPFEGIGKLEPLKFNLSGFWSRRINEEHRLIYSVEDEAILIVAC
RYHYDQ

Download         Length: 261 bp

>T191784 NZ_CP091904:2898692-2898835 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9362.66 Da        Isoelectric Point: 4.5659

>AT191784 WP_005598318.1 NZ_CP069796:1571074-1571325 [Actinobacillus pleuropneumoniae serovar 6 str. Femo]
MQAITYTEARQNLAGTMSKVAEDFEPILITRSKGGNCVLMSYEQYCSLEETAYLMRSPTNAKRLLDSVAELRQGQGIERE
LIE

Download         Length: 252 bp

>AT191784 NZ_CP091904:c2899029-2898767 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTACA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATATCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B0BQK9

Antitoxin

Source ID Structure
AlphaFold DB B0BQK8

References