Detailed information of TA system TA191780

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 1633426..1634071
• Replicon: chromosome
• Accession: NZ_CP069795
• Organism: Actinobacillus pleuropneumoniae strain A-85/14

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: B0BQU7
• Locus tag: JS559_RS07665
• Protein ID: WP_005619674.1
• Coordinates: 1633700..1634071 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: JS559_RS07660
• Protein ID: WP_005598477.1
• Coordinates: 1633426..1633719 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JS559_RS07630 (JS559_07630)	1628758..1629441	-	684	WP_005608586.1	arginine ABC transporter permease ArtM	-
JS559_RS07635 (JS559_07635)	1629441..1630112	-	672	WP_005612835.1	arginine ABC transporter permease ArtQ	-
JS559_RS07640 (JS559_07640)	1630118..1630837	-	720	WP_011848574.1	transporter substrate-binding domain-containing protein	-
JS559_RS07645 (JS559_07645)	1630857..1631591	-	735	WP_005598473.1	arginine ABC transporter ATP-binding protein ArtP	-
JS559_RS07650 (JS559_07650)	1631816..1632313	-	498	WP_005601953.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
JS559_RS07655 (JS559_07655)	1632386..1633348	+	963	WP_005619672.1	calcium/sodium antiporter	-
JS559_RS07660 (JS559_07660)	1633426..1633719	-	294	WP_005598477.1	helix-turn-helix domain-containing protein	Antitoxin
JS559_RS07665 (JS559_07665)	1633700..1634071	-	372	WP_005619674.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JS559_RS07670 (JS559_07670)	1634264..1636015	+	1752	WP_237611441.1	protein-disulfide reductase DsbD	-
JS559_RS07675 (JS559_07675)	1636073..1636642	+	570	WP_005601959.1	elongation factor P hydroxylase	-
JS559_RS07680 (JS559_07680)	1636686..1637540	-	855	WP_009874917.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (32-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-85)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 15066.57 Da
• Isoelectric Point: 10.4054

>T191780 WP_005619674.1 NZ_CP069795:c1634071-1633700 [Actinobacillus pleuropneumoniae]
MYEIVFYRDKRGREPVKEFLLRLLKERQEGSRERLHKISHHLSILHLHGTRAGENYIKHLEDRIWQLRPVGDCLLFASII
RGKFVLLHYFAKQNYRIPKREIERAKVRLADLQERIKDEPYWF

Nucleotide

• Length: 372 bp

>T191780 NZ_CP069795:c1634071-1633700 [Actinobacillus pleuropneumoniae]
ATGTATGAAATAGTCTTTTATCGAGATAAGCGGGGGAGAGAACCCGTAAAAGAATTTCTGTTAAGGCTGCTAAAAGAACG
ACAGGAAGGCAGTCGAGAACGATTACACAAAATCAGCCATCATTTGAGTATTTTACATTTGCACGGTACTCGAGCCGGTG
AGAATTATATTAAGCATTTGGAAGATCGTATTTGGCAGTTACGTCCGGTGGGCGATTGCCTGTTATTTGCAAGTATTATT
CGGGGAAAATTTGTGTTGTTGCATTATTTTGCCAAACAGAATTATCGAATTCCGAAACGAGAAATAGAACGTGCAAAAGT
TCGGTTGGCGGATTTACAGGAGAGAATAAAAGATGAGCCCTATTGGTTCTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10935.81 Da
• Isoelectric Point: 10.3120

>AT191780 WP_005598477.1 NZ_CP069795:c1633719-1633426 [Actinobacillus pleuropneumoniae]
MSPIGSSWTSFEQEIFDESEIAETQFRIRLILEIIETRQQLGISQRKLEKLSGVKQSMIARVEKGSVNPSLATVLKLLVP
LGKTLQIVPLDKNKTVR

Nucleotide

• Length: 294 bp

>AT191780 NZ_CP069795:c1633719-1633426 [Actinobacillus pleuropneumoniae]
ATGAGCCCTATTGGTTCTAGTTGGACATCGTTTGAACAAGAAATTTTTGACGAGTCGGAAATAGCGGAAACTCAGTTTCG
CATACGACTTATTTTAGAAATCATTGAAACCCGTCAGCAGCTCGGTATTTCTCAACGAAAATTGGAGAAATTAAGCGGCG
TAAAACAATCTATGATTGCTCGGGTAGAAAAAGGCTCGGTTAATCCGTCGTTGGCGACGGTATTAAAGTTGCTTGTGCCG
TTGGGGAAAACTTTACAAATCGTACCGTTAGATAAAAACAAAACGGTACGTTAA

Structures

Toxin

• AlphaFold DB: A3N206