Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YoeB-YefM |
| Location | 1546039..1546547 | Replicon | chromosome |
| Accession | NZ_CP069795 | ||
| Organism | Actinobacillus pleuropneumoniae strain A-85/14 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | JS559_RS07205 | Protein ID | WP_237611416.1 |
| Coordinates | 1546287..1546547 (+) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | B0BQK8 |
| Locus tag | JS559_RS07200 | Protein ID | WP_005598318.1 |
| Coordinates | 1546039..1546290 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JS559_RS07160 (JS559_07160) | 1541575..1542123 | - | 549 | WP_011848557.1 | type IV pilus biogenesis/stability protein PilW | - |
| JS559_RS07165 (JS559_07165) | 1542177..1543358 | - | 1182 | WP_009875290.1 | bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN | - |
| JS559_RS07190 (JS559_07190) | 1544262..1545701 | + | 1440 | WP_005605060.1 | glutamate--tRNA ligase | - |
| JS559_RS07200 (JS559_07200) | 1546039..1546290 | + | 252 | WP_005598318.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| JS559_RS07205 (JS559_07205) | 1546287..1546547 | + | 261 | WP_237611416.1 | Txe/YoeB family addiction module toxin | Toxin |
| JS559_RS07210 (JS559_07210) | 1546628..1547837 | + | 1210 | Protein_1411 | IS3 family transposase | - |
| JS559_RS07215 (JS559_07215) | 1548003..1548170 | - | 168 | WP_009875287.1 | Trm112 family protein | - |
| JS559_RS07220 (JS559_07220) | 1548172..1549152 | - | 981 | WP_237611417.1 | tetraacyldisaccharide 4'-kinase | - |
| JS559_RS07225 (JS559_07225) | 1549246..1550505 | - | 1260 | WP_005598324.1 | ATP-dependent protease ATP-binding subunit ClpX | - |
| JS559_RS07230 (JS559_07230) | 1550505..1551095 | - | 591 | WP_005601821.1 | ATP-dependent Clp endopeptidase proteolytic subunit ClpP | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 10407.94 Da Isoelectric Point: 8.0109
>T191779 WP_237611416.1 NZ_CP069795:1546287-1546547 [Actinobacillus pleuropneumoniae]
MKLTFSSNAWEDYLYWQKTDKIILKRINSLIKDIQRQPFEGIGKPEPLKFNLSGFWSRRINEEHRLIYSVEDEAILIVAC
RYHYDQ
MKLTFSSNAWEDYLYWQKTDKIILKRINSLIKDIQRQPFEGIGKPEPLKFNLSGFWSRRINEEHRLIYSVEDEAILIVAC
RYHYDQ
Download Length: 261 bp
>T191779 NZ_CP091903:41347-41457 [Enterococcus faecalis]
GTGTTATTTGTGAAAGATTTAATGTCGTTGGTTATCGCACCGATCTTTGTAGGATTGGTTCTGGAAATGATTTCTCGTGT
GTTGGACGAGGAAGACGATAACCGAAAGTAA
GTGTTATTTGTGAAAGATTTAATGTCGTTGGTTATCGCACCGATCTTTGTAGGATTGGTTCTGGAAATGATTTCTCGTGT
GTTGGACGAGGAAGACGATAACCGAAAGTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9362.66 Da Isoelectric Point: 4.5659
>AT191779 WP_005598318.1 NZ_CP069795:1546039-1546290 [Actinobacillus pleuropneumoniae]
MQAITYTEARQNLAGTMSKVAEDFEPILITRSKGGNCVLMSYEQYCSLEETAYLMRSPTNAKRLLDSVAELRQGQGIERE
LIE
MQAITYTEARQNLAGTMSKVAEDFEPILITRSKGGNCVLMSYEQYCSLEETAYLMRSPTNAKRLLDSVAELRQGQGIERE
LIE
Download Length: 252 bp
>AT191779 NZ_CP091903:c41561-41497 [Enterococcus faecalis]
AACGACATTAAATCGTACAAATAACACAAAAAGCAATCCTACGGCGAATAGGATTGCTTTTTTTT
AACGACATTAAATCGTACAAATAACACAAAAAGCAATCCTACGGCGAATAGGATTGCTTTTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|