Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 781939..782589 Replicon chromosome
Accession NZ_CP069795
Organism Actinobacillus pleuropneumoniae strain A-85/14

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JS559_RS03615 Protein ID WP_215577551.1
Coordinates 781939..782328 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JS559_RS03620 Protein ID WP_215577552.1
Coordinates 782329..782589 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JS559_RS03600 (JS559_03595) 777737..778777 + 1041 WP_005603118.1 IS481 family transposase -
JS559_RS03605 (JS559_03600) 778886..780172 - 1287 WP_237611191.1 Xaa-Pro aminopeptidase -
JS559_RS03610 (JS559_03605) 780581..781804 - 1224 WP_237611192.1 ATP-binding protein -
JS559_RS03615 (JS559_03610) 781939..782328 - 390 WP_215577551.1 type II toxin-antitoxin system VapC family toxin Toxin
JS559_RS03620 (JS559_03615) 782329..782589 - 261 WP_215577552.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JS559_RS03625 (JS559_03620) 782723..784744 - 2022 WP_005617154.1 excinuclease ABC subunit UvrB -
JS559_RS03630 (JS559_03625) 784921..785733 + 813 WP_005604121.1 iron uptake system protein EfeO -
JS559_RS03635 (JS559_03630) 785745..786938 + 1194 WP_237611193.1 iron uptake transporter deferrochelatase/peroxidase subunit -
JS559_RS03640 (JS559_03635) 786949..787569 + 621 WP_005596976.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 777737..778777 1040


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-117)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14793.16 Da        Isoelectric Point: 5.8397

>T191778 WP_215577551.1 NZ_CP069795:c782328-781939 [Actinobacillus pleuropneumoniae]
MYMLDTNTVSYFFRQEPTVVKKLQQLNPELICISSVTAAELFYGVKKRNNQKLTAFLNTFLSAITVMDWDYQVAEVYGQL
RAEMERGGKIMGVQDQMIGAHALATECILVSSDKAFQFIPNLVLENWWK

Download         Length: 390 bp

>T191778 NZ_CP091902:86771-86881 [Enterococcus faecalis]
GTGTTATTTGTGAAAGATTTAATGTCGTTGGTTATCGCACCGATCTTTGTAGGATTGGTTCTGGAAATGATTTCTCGTGT
GTTGGACGAGGAAGACGATAACCGAAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10289.67 Da        Isoelectric Point: 6.3511

>AT191778 WP_215577552.1 NZ_CP069795:c782589-782329 [Actinobacillus pleuropneumoniae]
MEKVARLFRNGRNQAVRLPVEFEFNAKQVYVFKEANGDITLSTRSRNQQNWQKVFELLPMLECDEQFLSEKERKQEMATR
DPFEGF

Download         Length: 261 bp

>AT191778 NZ_CP091902:c86985-86921 [Enterococcus faecalis]
AACGACATTAAATCGTACAAATAACACAAAAAGCAATCCTACGGCGAATAGGATTGCTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References