191775

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 28354..28819 Replicon plasmid pTA13-4
Accession NZ_CP069716
Organism Escherichia coli strain EA13

Toxin (Protein)


Gene name TsxA Uniprot ID U9ZUY2
Locus tag JSQ77_RS24610 Protein ID WP_001230707.1
Coordinates 28354..28605 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID M7CCF8
Locus tag JSQ77_RS24615 Protein ID WP_000801440.1
Coordinates 28592..28819 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSQ77_RS24585 23835..24362 - 528 WP_000577043.1 DUF2726 domain-containing protein -
JSQ77_RS24590 24497..24901 - 405 WP_012421203.1 hypothetical protein -
JSQ77_RS24595 24914..25780 - 867 WP_001353743.1 replication initiation protein -
JSQ77_RS24600 27195..27710 + 516 WP_001025395.1 J domain-containing protein -
JSQ77_RS24605 27815..28357 + 543 WP_001083906.1 hypothetical protein -
JSQ77_RS24610 28354..28605 + 252 WP_001230707.1 hypothetical protein Toxin
JSQ77_RS24615 28592..28819 + 228 WP_000801440.1 hypothetical protein Antitoxin
JSQ77_RS24620 29273..29572 + 300 WP_000650309.1 hypothetical protein -
JSQ77_RS24625 29663..30013 + 351 WP_000854259.1 hypothetical protein -
JSQ77_RS24630 30318..30566 + 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin -
JSQ77_RS24635 30563..30910 + 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin -
JSQ77_RS24640 31271..31774 + 504 WP_000781813.1 hypothetical protein -
JSQ77_RS24645 31778..33007 + 1230 WP_204084460.1 relaxase/mobilization nuclease domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-1.1 - 1..33309 33309


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9751.13 Da        Isoelectric Point: 8.9187

>T191775 WP_001230707.1 NZ_CP069716:28354-28605 [Escherichia coli]
MRKNKGDVTYFLEKEGDNYRLTKRIKARTNVKIGNKTTKITLYDAVLNENELQHIDFTCAGLREDDETPVKNLIKEFMLN
ETR

Download         Length: 252 bp

>T191775 NZ_CP091902:47752-48114 [Enterococcus faecalis]
ATGGTAAAAGTTCCTCATCAAGGTGATATTTTATTGTTGAATACGGCTCCTAGATCAGGACATGAACAAACAGGTAAGAG
ACCGTATATTGTTTTAAGTCATGATATTATTGCAGATTACAGCAATGTTGTTATTGTAGCTCCTATATCAAGTACAAAAA
GAAACTATCCTTTATATGTTTCTATTAATCCTTCTTACGGAATGAAAACATCAGGTAAAGTATTATTAGATCAATTAACC
ACCATCGATTATGAGGCTAGACAATGCGTGTTTTTAGAAACAGCACACGAAAAATTAATCGATGAATTATTGCTAAAAGT
TAGAACCGTATTTCAAAAAGTAAATAAAACAAATAAATTTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8659.98 Da        Isoelectric Point: 8.5105

>AT191775 WP_000801440.1 NZ_CP069716:28592-28819 [Escherichia coli]
MKPDNTPENVKKLRLKAGLTQKECSHIYGVGLRTWQKKEEVNTQNSQSLSLVEFEFLLLLAGEHPEYVLCKRESK

Download         Length: 228 bp

>AT191775 NZ_CP091902:47495-47758 [Enterococcus faecalis]
ATGGTAATGTTATCAATAAAAAAATGGGGCAATAGTAACGGTCTTAGACTTCCTAAATCTGTGATGGAATATCTCCAAAT
TCATACAGAAGATAAAGTGAAAATAACACAGGAGGAATCGAATGGTAAAAAACGATTAATTATTGAAGCTGTGGATTCTG
ATAATGATTTAACAATTGAACAATTGTTTGAAAATTATAAAGAAGAGAAGGTGCATGTAACTATTCAAGATTTAGGAAAT
GCGGTAGGAAATGAAAAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZUY2

Antitoxin

Source ID Structure
AlphaFold DB A0A5Y6U8W9

References