Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3491929..3492547 Replicon chromosome
Accession NZ_CP069712
Organism Escherichia coli strain EA13

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag JSQ77_RS16815 Protein ID WP_001291435.1
Coordinates 3492329..3492547 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag JSQ77_RS16810 Protein ID WP_112901457.1
Coordinates 3491929..3492303 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSQ77_RS16800 3487018..3488211 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JSQ77_RS16805 3488234..3491383 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
JSQ77_RS16810 3491929..3492303 + 375 WP_112901457.1 Hha toxicity modulator TomB Antitoxin
JSQ77_RS16815 3492329..3492547 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
JSQ77_RS16820 3492719..3493270 + 552 WP_000102564.1 maltose O-acetyltransferase -
JSQ77_RS16825 3493386..3493856 + 471 WP_000136192.1 YlaC family protein -
JSQ77_RS16830 3494020..3495570 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
JSQ77_RS16835 3495612..3495965 - 354 WP_000878140.1 DUF1428 domain-containing protein -
JSQ77_RS16845 3496344..3496655 + 312 WP_000409911.1 MGMT family protein -
JSQ77_RS16850 3496686..3497258 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T191762 WP_001291435.1 NZ_CP069712:3492329-3492547 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T191762 NZ_CP091899:2943023-2943127 [Enterococcus faecalis]
TTGTCAGCATATGAAACAATTCAGACAATTCTTGGGTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATT
GCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14530.36 Da        Isoelectric Point: 4.7395

>AT191762 WP_112901457.1 NZ_CP069712:3491929-3492303 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGISMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT191762 NZ_CP091899:c2943315-2943060 [Enterococcus faecalis]
ATAAAAATGCCCGAGCCTTGAAATAGGAGGCTCAGGCATTTTTTATTGATGGTCTTTTTAGGGTTGTTGTGCTATAATGA
TAAAGAAAAGAGAGATATGCTTCCAACATATCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCAATTTTATTATTTAAA
AATAACCGTGCTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCAATCAAAGCA
ATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References