Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2567947..2568473 Replicon chromosome
Accession NZ_CP069712
Organism Escherichia coli strain EA13

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag JSQ77_RS12365 Protein ID WP_000323025.1
Coordinates 2567947..2568234 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag JSQ77_RS12370 Protein ID WP_000534858.1
Coordinates 2568234..2568473 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSQ77_RS12330 2563337..2563552 - 216 WP_000839565.1 phage lysis protein EssD -
JSQ77_RS12335 2563804..2564178 - 375 WP_001348108.1 hypothetical protein -
JSQ77_RS12340 2564350..2564778 - 429 WP_000506936.1 cell envelope integrity protein TolA -
JSQ77_RS12345 2565823..2566365 - 543 WP_000640161.1 DUF1133 family protein -
JSQ77_RS12350 2566362..2566652 - 291 WP_000247763.1 DUF1364 domain-containing protein -
JSQ77_RS12355 2566652..2567251 - 600 WP_025670565.1 DUF1367 family protein -
JSQ77_RS12360 2567720..2567875 - 156 WP_000813269.1 type I toxin-antitoxin system toxin HokD -
JSQ77_RS12365 2567947..2568234 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
JSQ77_RS12370 2568234..2568473 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
JSQ77_RS12375 2568498..2568803 + 306 WP_071600497.1 hypothetical protein -
JSQ77_RS12380 2569006..2569338 + 333 WP_001349760.1 FlxA-like family protein -
JSQ77_RS12390 2571085..2572347 - 1263 WP_112901435.1 ISNCY family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2555302..2590261 34959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T191761 WP_000323025.1 NZ_CP069712:c2568234-2567947 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T191761 NZ_CP091899:2943023-2943127 [Enterococcus faecalis]
TTGTCAGCATATGAAACAATTCAGACAATTCTTGGGTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATT
GCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT191761 WP_000534858.1 NZ_CP069712:c2568473-2568234 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT191761 NZ_CP091899:c2942883-2942729 [Enterococcus faecalis]
TTTTTAGGTAAGTGTGCTATAATAGCAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCGGTTTAAGA
CGGTGACCTTTTGGATTATTTAAAAATAACCGTACTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCTTCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References