Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2465400..2466038 Replicon chromosome
Accession NZ_CP069712
Organism Escherichia coli strain EA13

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag JSQ77_RS11855 Protein ID WP_000813794.1
Coordinates 2465862..2466038 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JSQ77_RS11850 Protein ID WP_001270286.1
Coordinates 2465400..2465816 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSQ77_RS11830 2460552..2461493 - 942 WP_001251319.1 ABC transporter permease -
JSQ77_RS11835 2461494..2462507 - 1014 WP_000220393.1 ABC transporter ATP-binding protein -
JSQ77_RS11840 2462525..2463670 - 1146 WP_000047429.1 ABC transporter substrate-binding protein -
JSQ77_RS11845 2463912..2465321 - 1410 WP_000760625.1 PLP-dependent aminotransferase family protein -
JSQ77_RS11850 2465400..2465816 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
JSQ77_RS11855 2465862..2466038 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
JSQ77_RS11860 2466260..2466490 + 231 WP_000494244.1 YncJ family protein -
JSQ77_RS11865 2466582..2468543 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
JSQ77_RS11870 2468616..2469152 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
JSQ77_RS11875 2469205..2470419 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T191760 WP_000813794.1 NZ_CP069712:c2466038-2465862 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T191760 NZ_CP091899:c2771241-2771140 [Enterococcus faecalis]
TTGTCAATCGAAGCGACATTGGAATTGATGATTAGTTTTGCAACCCTTGTTGCGTTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT191760 WP_001270286.1 NZ_CP069712:c2465816-2465400 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT191760 NZ_CP091899:2771016-2771203 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAACGCAACAAGGGTTGCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References