Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1840031..1840862 Replicon chromosome
Accession NZ_CP069712
Organism Escherichia coli strain EA13

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag JSQ77_RS08690 Protein ID WP_000854814.1
Coordinates 1840031..1840405 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag JSQ77_RS08695 Protein ID WP_001285585.1
Coordinates 1840494..1840862 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSQ77_RS08650 1835427..1836593 + 1167 WP_001442313.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
JSQ77_RS08655 1836712..1837185 + 474 WP_001105393.1 DNA gyrase inhibitor SbmC -
JSQ77_RS08660 1837383..1838441 + 1059 WP_001200891.1 FUSC family protein -
JSQ77_RS08665 1838613..1838942 + 330 WP_000450409.1 DUF496 family protein -
JSQ77_RS08670 1839043..1839225 - 183 WP_072769026.1 ethanolamine utilization protein -
JSQ77_RS08675 1839297..1839425 + 129 Protein_1695 transposase domain-containing protein -
JSQ77_RS08680 1839714..1839827 - 114 WP_001161660.1 DUF957 domain-containing protein -
JSQ77_RS08685 1839840..1840034 - 195 WP_000988600.1 hypothetical protein -
JSQ77_RS08690 1840031..1840405 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
JSQ77_RS08695 1840494..1840862 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
JSQ77_RS08700 1840936..1841157 - 222 WP_000692323.1 DUF987 domain-containing protein -
JSQ77_RS08705 1841220..1841696 - 477 WP_001186773.1 RadC family protein -
JSQ77_RS08710 1841712..1842191 - 480 WP_000860076.1 antirestriction protein -
JSQ77_RS08715 1842273..1843094 - 822 WP_001234530.1 DUF945 domain-containing protein -
JSQ77_RS08720 1843315..1843725 - 411 WP_000846713.1 hypothetical protein -
JSQ77_RS08725 1843741..1844424 - 684 WP_000775500.1 hypothetical protein -
JSQ77_RS08730 1844560..1845630 - 1071 WP_000102643.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T191750 WP_000854814.1 NZ_CP069712:c1840405-1840031 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T191750 NZ_CP091897:c1518550-1517687 [Enterococcus faecalis]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTC
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGCG
AAACTTTATGAGAAAGACGTAGTAAAACACGTCACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGCTATAATTTAGTGATTGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTTATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACTATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GATTAGAAACGCCTTCTATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGCTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
AATGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGACTTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT191750 WP_001285585.1 NZ_CP069712:c1840862-1840494 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT191750 NZ_CP091897:c1518824-1518552 [Enterococcus faecalis]
ATGGCAGTTACATATGAAAAAACATTTGAAATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References