Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 102732..103254 Replicon plasmid pTA2-1
Accession NZ_CP069711
Organism Escherichia coli strain EA2

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag JSQ74_RS23445 Protein ID WP_000220560.1
Coordinates 102973..103254 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag JSQ74_RS23440 Protein ID WP_000121743.1
Coordinates 102732..102983 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSQ74_RS23415 98403..98684 + 282 WP_001185482.1 hypothetical protein -
JSQ74_RS23420 98709..99686 + 978 WP_024245156.1 hypothetical protein -
JSQ74_RS23425 99683..100108 - 426 WP_000202942.1 hypothetical protein -
JSQ74_RS23430 100176..100622 - 447 Protein_107 hypothetical protein -
JSQ74_RS23435 100662..101498 - 837 WP_001050931.1 replication initiation protein -
JSQ74_RS23440 102732..102983 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
JSQ74_RS23445 102973..103254 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JSQ74_RS23450 103329..104026 + 698 Protein_111 IS1 family transposase -
JSQ74_RS23455 104036..104203 + 168 Protein_112 replication initiation protein -
JSQ74_RS23460 104256..104960 - 705 WP_001067858.1 IS6-like element IS26 family transposase -
JSQ74_RS23465 105005..105373 - 369 Protein_114 IS6 family transposase -
JSQ74_RS23470 105640..107076 + 1437 WP_000105383.1 glutathione synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid qnrS1 / oqxA / oqxB / floR / ant(3'')-Ia / cmlA1 / aadA2 / dfrA12 / tet(A) / blaTEM-1B / sul3 / tet(M) / aph(3')-Ia / mph(A) - 1..120379 120379


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T191742 WP_000220560.1 NZ_CP069711:102973-103254 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T191742 NZ_CP091895:c1518671-1517808 [Enterococcus faecalis]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTC
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGCG
AAACTTTATGAGAAAGACGTAGTAAAACACGTCACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGCTATAATTTAGTGATTGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTTATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACTATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GATTAGAAACGCCTTCTATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGCTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
AATGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGACTTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT191742 WP_000121743.1 NZ_CP069711:102732-102983 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT191742 NZ_CP091895:c1518945-1518673 [Enterococcus faecalis]
ATGGCAGTTACATATGAAAAAACATTTGAAATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References