Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3408359..3408977 Replicon chromosome
Accession NZ_CP069709
Organism Escherichia coli strain EA7

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag JSQ43_RS17040 Protein ID WP_001291435.1
Coordinates 3408759..3408977 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag JSQ43_RS17035 Protein ID WP_000344800.1
Coordinates 3408359..3408733 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSQ43_RS17025 3403448..3404641 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JSQ43_RS17030 3404664..3407813 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
JSQ43_RS17035 3408359..3408733 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
JSQ43_RS17040 3408759..3408977 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
JSQ43_RS17045 3409149..3409700 + 552 WP_000102564.1 maltose O-acetyltransferase -
JSQ43_RS17050 3409816..3410286 + 471 WP_000136192.1 YlaC family protein -
JSQ43_RS17055 3410450..3412000 + 1551 WP_105075348.1 cyclic-guanylate-specific phosphodiesterase PdeB -
JSQ43_RS17060 3412042..3412395 - 354 WP_000878140.1 DUF1428 domain-containing protein -
JSQ43_RS17070 3412774..3413085 + 312 WP_000409911.1 MGMT family protein -
JSQ43_RS17075 3413116..3413688 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T191714 WP_001291435.1 NZ_CP069709:3408759-3408977 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T191714 NZ_CP091889:2691065-2691409 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTAGAAGAATATAATGTGGAGTTAGTTTTTACTACTTTGAATAAACGCGCATGTTTCGA
CCCTACCTACGGTATCATATTTGTAAATCAAAATTTAACACCATCAGAACAAGAAGAAGCAATATATCACGAATTAAAGC
ATGTAAAAGACCATGTGGATATAATGGAATTGTATAAAATTCCTGTTTTTCGTTCTAAGATGGAATCCGAAGCAGAACAA
TATATGTTTAGAAGCTTAATCGAAAAATATGAAGGACAATACAATTACTCAAATGTTATAGCTCATTACAACTTAAAAAT
GGGACAAGAAGTTTATTTGAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT191714 WP_000344800.1 NZ_CP069709:3408359-3408733 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT191714 NZ_CP091889:2690714-2691046 [Enterococcus faecalis]
ATGAATACTTACGAAATAATAAAAGACTTAGCTAAAGAAAAAGGAATTTCTATTAGACAATTGGAAATAAATTTTGGCTA
CTCTAATGGATATATCGGTAGTTGGAAAAGACAAACACCCAATTCTAATGAATTAAGTCGTTTAGCAGACTACTTTGATG
TATCTGTAGATTATCTATTGGGAAGAACTGATAATACTAAAGCAACTGATGAAAAAAAATTTGATGATTTAGATGATGTA
CTGGATAACGTCATGAGTTTTGACGGTGAACCACTTGATGATCATGACAGAGAAGTTATTCGTGCATATTTAAAGGGTAG
ATTCGGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References