Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 694308..695143 Replicon chromosome
Accession NZ_CP069709
Organism Escherichia coli strain EA7

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7W4PV54
Locus tag JSQ43_RS03745 Protein ID WP_000854821.1
Coordinates 694766..695143 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A4Q1HU91
Locus tag JSQ43_RS03740 Protein ID WP_053287563.1
Coordinates 694308..694676 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSQ43_RS03720 692052..692870 + 819 WP_088209827.1 DUF945 domain-containing protein -
JSQ43_RS03725 692962..693447 + 486 WP_001559912.1 antirestriction protein -
JSQ43_RS03730 693462..693938 + 477 WP_040076129.1 RadC family protein -
JSQ43_RS03735 694007..694228 + 222 WP_000692309.1 DUF987 domain-containing protein -
JSQ43_RS03740 694308..694676 + 369 WP_053287563.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JSQ43_RS03745 694766..695143 + 378 WP_000854821.1 type IV toxin-antitoxin system toxin CbtA Toxin
JSQ43_RS03750 695140..695337 + 198 Protein_651 hypothetical protein -
JSQ43_RS03755 695365..695562 + 198 WP_088209831.1 DUF957 domain-containing protein -
JSQ43_RS03760 695647..696492 + 846 WP_063101552.1 DUF4942 domain-containing protein -
JSQ43_RS03770 696791..697297 + 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
JSQ43_RS03775 697376..699217 - 1842 WP_000437375.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13930.95 Da        Isoelectric Point: 8.5163

>T191700 WP_000854821.1 NZ_CP069709:694766-695143 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T191700 NZ_CP091884:2853299-2853442 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13663.36 Da        Isoelectric Point: 6.4768

>AT191700 WP_053287563.1 NZ_CP069709:694308-694676 [Escherichia coli]
VSDTFSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNSRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT191700 NZ_CP091884:c2853636-2853374 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W4PV54

Antitoxin

Source ID Structure
AlphaFold DB A0A4Q1HU91

References