Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 54040..54562 Replicon plasmid pTA7-1
Accession NZ_CP069708
Organism Escherichia coli strain EA7

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag JSQ43_RS00270 Protein ID WP_000220560.1
Coordinates 54040..54321 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag JSQ43_RS00275 Protein ID WP_000121743.1
Coordinates 54311..54562 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSQ43_RS00235 49251..50465 + 1215 WP_058100717.1 chloramphenicol/florfenicol efflux MFS transporter FloR -
JSQ43_RS00240 50493..50798 + 306 WP_001255015.1 LysR family transcriptional regulator -
JSQ43_RS00245 50910..51071 + 162 Protein_48 IS91 family transposase -
JSQ43_RS00250 51160..52116 + 957 WP_063609966.1 IS21 family transposase -
JSQ43_RS00255 52153..52857 + 705 WP_001067858.1 IS6-like element IS26 family transposase -
JSQ43_RS00260 52950..53258 - 309 Protein_51 replication initiation protein -
JSQ43_RS00265 53268..53965 - 698 Protein_52 IS1 family transposase -
JSQ43_RS00270 54040..54321 - 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JSQ43_RS00275 54311..54562 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
JSQ43_RS00280 55796..56632 + 837 WP_001050931.1 replication initiation protein -
JSQ43_RS00285 56672..57118 + 447 Protein_56 hypothetical protein -
JSQ43_RS00290 57186..57611 + 426 WP_000202942.1 hypothetical protein -
JSQ43_RS00295 57608..58585 - 978 WP_024245156.1 hypothetical protein -
JSQ43_RS00300 58610..58891 - 282 WP_001185482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid tet(A) / blaTEM-1B / floR / tet(M) / ant(3'')-Ia / cmlA1 / aadA2 / dfrA12 - 1..77243 77243


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T191698 WP_000220560.1 NZ_CP069708:c54321-54040 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T191698 NZ_CP091884:c2709116-2709015 [Enterococcus faecalis]
TTGTCAATCGAAGCGACATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT191698 WP_000121743.1 NZ_CP069708:c54562-54311 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT191698 NZ_CP091884:2708892-2709070 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCG
AAAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References