Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3610923..3611541 Replicon chromosome
Accession NZ_CP069707
Organism Escherichia coli strain E41

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag JSQ86_RS17720 Protein ID WP_001291435.1
Coordinates 3611323..3611541 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag JSQ86_RS17715 Protein ID WP_000344800.1
Coordinates 3610923..3611297 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSQ86_RS17705 3606012..3607205 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JSQ86_RS17710 3607228..3610377 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
JSQ86_RS17715 3610923..3611297 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
JSQ86_RS17720 3611323..3611541 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
JSQ86_RS17725 3611713..3612264 + 552 WP_000102564.1 maltose O-acetyltransferase -
JSQ86_RS17730 3612380..3612850 + 471 WP_000136192.1 YlaC family protein -
JSQ86_RS17735 3613014..3614564 + 1551 WP_096976878.1 cyclic-guanylate-specific phosphodiesterase PdeB -
JSQ86_RS17740 3614606..3614959 - 354 WP_000878140.1 DUF1428 domain-containing protein -
JSQ86_RS17750 3615338..3615649 + 312 WP_000409911.1 MGMT family protein -
JSQ86_RS17755 3615680..3616252 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T191695 WP_001291435.1 NZ_CP069707:3611323-3611541 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T191695 NZ_CP091884:424914-425189 [Enterococcus faecalis]
ATGCTTGAAATATTTTACACGAACCAATTCAAAAAAGACTTTAAGAAAGCAAAGAAACAAGGAAAGAATTTAGAGAAGTT
AAAAGAAGTATTAGTACTTTTACAAGAACAGCAAACATTGCCGCCAAAGTATAAAGACCACGCACTAACAGGAAATTATA
TAGGTACAAGAGAGTGCCATATTGAACCAGATTGGTTACTGATTTATAAAATTGACGGTGATAAATTGATCCTAACTTTA
GCTCGAATAGGCTCACATAGTGAATTATTTCGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT191695 WP_000344800.1 NZ_CP069707:3610923-3611297 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT191695 NZ_CP091884:424655-424921 [Enterococcus faecalis]
GTGGCTACTACAAAAAAGAAACCTATACATGTAAATGTTGATGAAAATTTAAAAGAAGAAGCAGAACAATTATTTGATGA
TTTAGGGTTAAATATGACAAGTGCAATTACGATTTTCTTAAAACAGTCTATTAATGAGCAAGCAATTCCTTTTATGATTA
ATAAGGGAAACAAAGAGACTCTACAAGCATTAAAAGACATTAAAGAAGGAAATGTTCATGGTGGATTTTCTTCCGTGGAG
GATTTAATGGAGGATTTAAATGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References