Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3610923..3611541 Replicon chromosome
Accession NZ_CP069707
Organism Escherichia coli strain E41

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag JSQ86_RS17720 Protein ID WP_001291435.1
Coordinates 3611323..3611541 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag JSQ86_RS17715 Protein ID WP_000344800.1
Coordinates 3610923..3611297 (+) Length 125 a.a.

Genomic Context


JSQ86_RS17705JSQ86_RS17710JSQ86_RS17715JSQ86_RS17720JSQ86_RS17725JSQ86_RS17730JSQ86_RS17735JSQ86_RS17750JSQ86_RS17740JSQ86_RS17755
Location: 3606012..3607205 (1194 bp)
Type: Others
Protein ID: WP_001295324.1
Location: 3607228..3610377 (3150 bp)
Type: Others
Protein ID: WP_001132469.1
Location: 3610923..3611297 (375 bp)
Type: Antitoxin
Protein ID: WP_000344800.1
Location: 3611323..3611541 (219 bp)
Type: Toxin
Protein ID: WP_001291435.1
Location: 3611713..3612264 (552 bp)
Type: Others
Protein ID: WP_000102564.1
Location: 3612380..3612850 (471 bp)
Type: Others
Protein ID: WP_000136192.1
Location: 3613014..3614564 (1551 bp)
Type: Others
Protein ID: WP_096976878.1
Location: 3615338..3615649 (312 bp)
Type: Others
Protein ID: WP_000409911.1
Location: 3614606..3614959 (354 bp)
Type: Others
Protein ID: WP_000878140.1
Location: 3615680..3616252 (573 bp)
Type: Others
Protein ID: WP_000779831.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
JSQ86_RS177053606012..3607205+1194WP_001295324.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-
JSQ86_RS177103607228..3610377+3150WP_001132469.1multidrug efflux RND transporter permease subunit-
JSQ86_RS177153610923..3611297+375WP_000344800.1Hha toxicity modulator TomBAntitoxin
JSQ86_RS177203611323..3611541+219WP_001291435.1hemolysin expression modulator HhaToxin
JSQ86_RS177253611713..3612264+552WP_000102564.1maltose O-acetyltransferase-
JSQ86_RS177303612380..3612850+471WP_000136192.1YlaC family protein-
JSQ86_RS177353613014..3614564+1551WP_096976878.1cyclic-guanylate-specific phosphodiesterase PdeB-
JSQ86_RS177403614606..3614959-354WP_000878140.1DUF1428 domain-containing protein-
JSQ86_RS177503615338..3615649+312WP_000409911.1MGMT family protein-
JSQ86_RS177553615680..3616252-573WP_000779831.1YbaY family lipoprotein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-69)

Antitoxin

(1-117)


Sequences


Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T191695 WP_001291435.1 NZ_CP069707:3611323-3611541 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T191695 NZ_CP091884:424914-425189 [Enterococcus faecalis]
ATGCTTGAAATATTTTACACGAACCAATTCAAAAAAGACTTTAAGAAAGCAAAGAAACAAGGAAAGAATTTAGAGAAGTT
AAAAGAAGTATTAGTACTTTTACAAGAACAGCAAACATTGCCGCCAAAGTATAAAGACCACGCACTAACAGGAAATTATA
TAGGTACAAGAGAGTGCCATATTGAACCAGATTGGTTACTGATTTATAAAATTGACGGTGATAAATTGATCCTAACTTTA
GCTCGAATAGGCTCACATAGTGAATTATTTCGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT191695 WP_000344800.1 NZ_CP069707:3610923-3611297 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT191695 NZ_CP091884:424655-424921 [Enterococcus faecalis]
GTGGCTACTACAAAAAAGAAACCTATACATGTAAATGTTGATGAAAATTTAAAAGAAGAAGCAGAACAATTATTTGATGA
TTTAGGGTTAAATATGACAAGTGCAATTACGATTTTCTTAAAACAGTCTATTAATGAGCAAGCAATTCCTTTTATGATTA
ATAAGGGAAACAAAGAGACTCTACAAGCATTAAAAGACATTAAAGAAGGAAATGTTCATGGTGGATTTTCTTCCGTGGAG
GATTTAATGGAGGATTTAAATGCTTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
PDB2MW2
PDB1JW2


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7U9QBQ5

References