Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3027739..3028210 Replicon chromosome
Accession NZ_CP069707
Organism Escherichia coli strain E41

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag JSQ86_RS14885 Protein ID WP_001303511.1
Coordinates 3027932..3028210 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag JSQ86_RS14880 Protein ID WP_001302048.1
Coordinates 3027739..3027930 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSQ86_RS14830 3022848..3023717 - 870 WP_000207991.1 DUF551 domain-containing protein -
JSQ86_RS14835 3023728..3023991 - 264 WP_000224233.1 hypothetical protein -
JSQ86_RS14840 3023993..3024210 - 218 Protein_2908 DUF4014 family protein -
JSQ86_RS14845 3024243..3024455 - 213 WP_000935421.1 hypothetical protein -
JSQ86_RS14850 3024506..3024862 - 357 WP_024249813.1 hypothetical protein -
JSQ86_RS14855 3024920..3025342 - 423 WP_001151130.1 DUF977 family protein -
JSQ86_RS14860 3025383..3026453 - 1071 WP_191642465.1 phage replisome organizer -
JSQ86_RS14865 3026525..3026950 - 426 WP_001678565.1 hypothetical protein -
JSQ86_RS14870 3026947..3027249 - 303 WP_204098011.1 transcriptional regulator -
JSQ86_RS14875 3027347..3027718 + 372 WP_122985828.1 hypothetical protein -
JSQ86_RS14880 3027739..3027930 + 192 WP_001302048.1 hypothetical protein Antitoxin
JSQ86_RS14885 3027932..3028210 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JSQ86_RS14890 3028502..3028657 + 156 WP_032154077.1 DUF1391 family protein -
JSQ86_RS14895 3028798..3029424 + 627 WP_203373727.1 hypothetical protein -
JSQ86_RS14900 3029425..3029634 - 210 WP_033813301.1 hypothetical protein -
JSQ86_RS14905 3030202..3030390 + 189 WP_086625363.1 cell division inhibition protein DicB -
JSQ86_RS14910 3030387..3030590 + 204 WP_086625364.1 DUF1482 family protein -
JSQ86_RS14915 3030671..3033154 + 2484 WP_204098012.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - ompA 3018740..3063937 45197


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T191694 WP_001303511.1 NZ_CP069707:3027932-3028210 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T191694 NZ_CP091884:c333036-332941 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT191694 WP_001302048.1 NZ_CP069707:3027739-3027930 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT191694 NZ_CP091884:332841-332906 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATCAGTAGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References