Detailed information of TA system TA191683

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 962282..962936
• Replicon: chromosome
• Accession: NZ_CP069707
• Organism: Escherichia coli strain E41

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: S1PAM6
• Locus tag: JSQ86_RS04770
• Protein ID: WP_000244781.1
• Coordinates: 962529..962936 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: JSQ86_RS04765
• Protein ID: WP_204098142.1
• Coordinates: 962282..962548 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JSQ86_RS04740	957451..958194	+	744	WP_000951964.1	SDR family oxidoreductase	-
JSQ86_RS04745	958251..959684	-	1434	WP_001336277.1	6-phospho-beta-glucosidase BglA	-
JSQ86_RS04750	959729..960040	+	312	WP_001182957.1	N(4)-acetylcytidine aminohydrolase	-
JSQ86_RS04755	960204..960863	+	660	WP_000250274.1	hemolysin III family protein	-
JSQ86_RS04760	961059..962039	-	981	WP_000886083.1	tRNA-modifying protein YgfZ	-
JSQ86_RS04765	962282..962548	+	267	WP_204098142.1	FAD assembly factor SdhE	Antitoxin
JSQ86_RS04770	962529..962936	+	408	WP_000244781.1	protein YgfX	Toxin
JSQ86_RS04775	962976..963497	-	522	WP_001055874.1	flavodoxin FldB	-
JSQ86_RS04780	963609..964505	+	897	WP_096904931.1	site-specific tyrosine recombinase XerD	-
JSQ86_RS04785	964530..965240	+	711	WP_000715214.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
JSQ86_RS04790	965246..966979	+	1734	WP_204098143.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 16061.99 Da
• Isoelectric Point: 11.5202

>T191683 WP_000244781.1 NZ_CP069707:962529-962936 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Nucleotide

• Length: 408 bp

>T191683 NZ_CP091878:c4313701-4313210 [Salmonella enterica subsp. enterica serovar Tennessee]
ATGATCTCCTCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGCGGGTGGGGTTTGAACCATCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10561.15 Da
• Isoelectric Point: 5.1700

>AT191683 WP_204098142.1 NZ_CP069707:962282-962548 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT191683 NZ_CP091878:c4313991-4313698 [Salmonella enterica subsp. enterica serovar Tennessee]
ATGTCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCACAGGCTTATCAGGAATTTCTCGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCACCGTGGGAGCAGGAAAAATGA

Structures

Toxin

• AlphaFold DB: S1PAM6