Detailed information of TA system TA191678

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 49388..50227
• Replicon: chromosome
• Accession: NZ_CP069707
• Organism: Escherichia coli strain E41

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: JSQ86_RS00260
• Protein ID: WP_097434451.1
• Coordinates: 49388..49765 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: JSQ86_RS00265
• Protein ID: WP_077249796.1
• Coordinates: 49814..50227 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JSQ86_RS00230	45196..46119	-	924	WP_000535963.1	carboxylate/amino acid/amine transporter	-
JSQ86_RS00235	46230..46562	-	333	Protein_46	MFS transporter	-
JSQ86_RS00240	46618..47315	+	698	Protein_47	IS1 family transposase	-
JSQ86_RS00245	47737..48595	-	859	Protein_48	DUF4942 domain-containing protein	-
JSQ86_RS00250	48676..48870	-	195	WP_038633777.1	DUF957 domain-containing protein	-
JSQ86_RS00255	48900..49391	-	492	WP_040063379.1	hypothetical protein	-
JSQ86_RS00260	49388..49765	-	378	WP_097434451.1	TA system toxin CbtA family protein	Toxin
JSQ86_RS00265	49814..50227	-	414	WP_077249796.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
JSQ86_RS00270	50196..50417	-	222	WP_038633763.1	DUF987 domain-containing protein	-
JSQ86_RS00275	50429..50914	-	486	WP_038642868.1	DNA repair protein RadC	-
JSQ86_RS00280	50967..51362	-	396	WP_051594539.1	antirestriction protein	-
JSQ86_RS00285	51440..51703	-	264	WP_038633754.1	hypothetical protein	-
JSQ86_RS00290	51703..52521	-	819	WP_001234374.1	DUF945 domain-containing protein	-
JSQ86_RS00295	52637..52887	-	251	Protein_58	DUF905 family protein	-
JSQ86_RS00300	53078..53545	-	468	WP_000727137.1	hypothetical protein	-
JSQ86_RS00305	53642..54043	-	402	WP_000819262.1	hypothetical protein	-
JSQ86_RS00310	54249..55136	-	888	WP_038633742.1	50S ribosome-binding GTPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (33-132)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13988.81 Da
• Isoelectric Point: 6.8604

>T191678 WP_097434451.1 NZ_CP069707:c49765-49388 [Escherichia coli]
MQTQPVSPAREASPRLSPVEIWQRLLSHLLDHHYGLALNDTPFGNDDVIQEHIDAGISLCDAVNFIVEKYDLVRTDRYGS
STTEQSPLISSIDILRARKACGLMTRNGYRAVTDITTGKYSKVTR

Nucleotide

• Length: 378 bp

>T191678 NZ_CP091878:2474942-2475226 [Salmonella enterica subsp. enterica serovar Tennessee]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACTATACAGGAACAGTTTAA
AAAAAAGTTACGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACGACACAGAAGCTAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15178.32 Da
• Isoelectric Point: 7.7885

>AT191678 WP_077249796.1 NZ_CP069707:c50227-49814 [Escherichia coli]
MSFCAASPSVNSYSRSTTLLNKTLPANHHISEPWWGLKRNITPCFGARLVQEGNRLHYLADRASITGTFTDADLRHLDQA
FPVLLKQMELMLVSGELSPRHQHCVTLYAKGLTCEADSLGSHGYIYIAIYPTPSVTS

Nucleotide

• Length: 414 bp

>AT191678 NZ_CP091878:2474704-2474952 [Salmonella enterica subsp. enterica serovar Tennessee]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA