Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sanaTA/AbiEii-DUF6088 |
| Location | 4101524..4102859 | Replicon | chromosome |
| Accession | NZ_CP069706 | ||
| Organism | Escherichia coli strain ECY44 | ||
Toxin (Protein)
| Gene name | sanaT | Uniprot ID | A0A3L9IFW6 |
| Locus tag | JR341_RS22820 | Protein ID | WP_038977127.1 |
| Coordinates | 4101524..4102471 (-) | Length | 316 a.a. |
Antitoxin (Protein)
| Gene name | sanaA | Uniprot ID | A0A3L2P891 |
| Locus tag | JR341_RS22825 | Protein ID | WP_038977126.1 |
| Coordinates | 4102464..4102859 (-) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JR341_RS22800 | 4097960..4098676 | + | 717 | WP_001295734.1 | N-acetylneuraminic acid outer membrane channel NanC | - |
| JR341_RS22805 | 4098696..4099802 | + | 1107 | WP_033870974.1 | N-acetylneuraminate epimerase | - |
| JR341_RS22810 | 4099867..4100847 | + | 981 | WP_057075671.1 | 9-O-acetyl-N-acetylneuraminic acid deacetylase | - |
| JR341_RS22815 | 4100855..4100977 | - | 123 | WP_001338066.1 | hypothetical protein | - |
| JR341_RS22820 | 4101524..4102471 | - | 948 | WP_038977127.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| JR341_RS22825 | 4102464..4102859 | - | 396 | WP_038977126.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
| JR341_RS22830 | 4102929..4103762 | - | 834 | WP_038977125.1 | DUF4942 domain-containing protein | - |
| JR341_RS22835 | 4103893..4104228 | - | 336 | WP_038977124.1 | TA system toxin CbtA family protein | - |
| JR341_RS22840 | 4104259..4104594 | - | 336 | WP_000939437.1 | type IV toxin-antitoxin system YeeU family antitoxin | - |
| JR341_RS22845 | 4104594..4105067 | - | 474 | WP_038977123.1 | DNA repair protein RadC | - |
| JR341_RS22850 | 4105097..4105915 | - | 819 | WP_033800492.1 | DUF945 domain-containing protein | - |
| JR341_RS22855 | 4106151..4107104 | - | 954 | WP_038977122.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 316 a.a. Molecular weight: 35634.77 Da Isoelectric Point: 4.8847
>T191674 WP_038977127.1 NZ_CP069706:c4102471-4101524 [Escherichia coli]
MDDLTTLFSEVADALGIESVAIVEKDHYIVELLQLLKPLVFDTHQLVFAGGTALAKSSVALNRMSEDVDIKLVPKDAFQA
LSRTQRKNTRKEIVQAVSSAIASSGVFNFDDDYPKVTRDEYRYNDIPVRYPQRVVQAPCLRPFIRLELMEAKLLEPSELR
DIHSLVTGITGKAAIVSAFPCATIISTQAEKLVAMLRRTAAVVRDVERFDDASLVRHIYDTNCIVETSHVDMSQLVDFVQ
QTIEQDIQRYGNQYPQFCASPVDELKMGLDELANNPLYEMRYQQFVSPMVYGERKITWDEAYSRFRSLALAILNA
MDDLTTLFSEVADALGIESVAIVEKDHYIVELLQLLKPLVFDTHQLVFAGGTALAKSSVALNRMSEDVDIKLVPKDAFQA
LSRTQRKNTRKEIVQAVSSAIASSGVFNFDDDYPKVTRDEYRYNDIPVRYPQRVVQAPCLRPFIRLELMEAKLLEPSELR
DIHSLVTGITGKAAIVSAFPCATIISTQAEKLVAMLRRTAAVVRDVERFDDASLVRHIYDTNCIVETSHVDMSQLVDFVQ
QTIEQDIQRYGNQYPQFCASPVDELKMGLDELANNPLYEMRYQQFVSPMVYGERKITWDEAYSRFRSLALAILNA
Download Length: 948 bp
>T191674 NZ_CP091878:336330-336698 [Salmonella enterica subsp. enterica serovar Tennessee]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTATCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCACTATATCCCGTGGGTATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGCGCCTGA
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTATCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCACTATATCCCGTGGGTATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGCGCCTGA
Antitoxin
Download Length: 132 a.a. Molecular weight: 14586.86 Da Isoelectric Point: 11.5650
>AT191674 WP_038977126.1 NZ_CP069706:c4102859-4102464 [Escherichia coli]
MTIKARIQSRLKRSKRYVFTRDDFKDIAGYDQVGRVLRDLVREGQLLKVGYGVYTKARRNGITGKVMPAAPGGSSAVIVE
TLERLKVHYRFAGATQAYNSGTSTQIPASPEIKTPRRFKRVLSVGNSRLNG
MTIKARIQSRLKRSKRYVFTRDDFKDIAGYDQVGRVLRDLVREGQLLKVGYGVYTKARRNGITGKVMPAAPGGSSAVIVE
TLERLKVHYRFAGATQAYNSGTSTQIPASPEIKTPRRFKRVLSVGNSRLNG
Download Length: 396 bp
>AT191674 NZ_CP091878:336112-336333 [Salmonella enterica subsp. enterica serovar Tennessee]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTAACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGAAGCTGGCGGATAAATGA
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTAACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGAAGCTGGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3L9IFW6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3L2P891 |