Detailed information of TA system TA191670

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2310255..2311843
• Replicon: chromosome
• Accession: NZ_CP069706
• Organism: Escherichia coli strain ECY44

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: E9TB78
• Locus tag: JR341_RS14240
• Protein ID: WP_001125466.1
• Coordinates: 2310521..2311843 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: JR341_RS14235
• Protein ID: WP_001296726.1
• Coordinates: 2310255..2310521 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JR341_RS14235	2310255..2310521	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
JR341_RS14240	2310521..2311843	+	1323	WP_001125466.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
JR341_RS14245	2312155..2312363	+	209	Protein_2222	helix-turn-helix transcriptional regulator	-
JR341_RS14250	2312795..2313358	+	564	WP_001296758.1	type 1 fimbrial major subunit FimA	-
JR341_RS14255	2313719..2314429	+	711	WP_053264576.1	fimbria/pilus periplasmic chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimA	2310255..2326344	16089

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49438.05 Da
• Isoelectric Point: 9.1005

>T191670 WP_001125466.1 NZ_CP069706:2310521-2311843 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHYLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Nucleotide

• Length: 1323 bp

>T191670 NZ_CP091876:c960844-960749 [Staphylococcus aureus]
GTGATGCTTATTTCCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT191670 WP_001296726.1 NZ_CP069706:2310255-2310521 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT191670 NZ_CP091876:960662-960721 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG