191660

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1451558..1452183 Replicon chromosome
Accession NZ_CP069706
Organism Escherichia coli strain ECY44

Toxin (Protein)


Gene name vapC Uniprot ID A0A2J1DF47
Locus tag JR341_RS09930 Protein ID WP_000911331.1
Coordinates 1451785..1452183 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag JR341_RS09925 Protein ID WP_000450524.1
Coordinates 1451558..1451785 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR341_RS09900 1447361..1447831 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
JR341_RS09905 1447831..1448403 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
JR341_RS09910 1448549..1449427 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
JR341_RS09915 1449444..1450478 + 1035 WP_057075645.1 outer membrane protein assembly factor BamC -
JR341_RS09920 1450691..1451404 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
JR341_RS09925 1451558..1451785 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
JR341_RS09930 1451785..1452183 + 399 WP_000911331.1 tRNA(fMet)-specific endonuclease VapC Toxin
JR341_RS09935 1452330..1453193 + 864 WP_001267507.1 neutral zinc metallopeptidase -
JR341_RS09940 1453208..1455223 + 2016 WP_001543081.1 tRNA cytosine(34) acetyltransferase TmcA -
JR341_RS09945 1455297..1455995 + 699 WP_000679812.1 esterase -
JR341_RS09950 1456105..1456305 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14862.19 Da        Isoelectric Point: 9.2216

>T191660 WP_000911331.1 NZ_CP069706:1451785-1452183 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLVELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T191660 NZ_CP091875:c2626699-2626433 [Staphylococcus aureus]
ATGGTTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTAATTAAAAGTATTGACAGAAATGGTGCGTTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT191660 WP_000450524.1 NZ_CP069706:1451558-1451785 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT191660 NZ_CP091875:c2626950-2626699 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATAGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTGTAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J1DF47

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References