Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TsxAB/MqsA(antitoxin) |
Location | 7053..7546 | Replicon | plasmid pECY44-4 |
Accession | NZ_CP069705 | ||
Organism | Escherichia coli strain ECY44 |
Toxin (Protein)
Gene name | TsxA | Uniprot ID | U9Y9W8 |
Locus tag | JR341_RS02570 | Protein ID | WP_001230709.1 |
Coordinates | 7053..7307 (+) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | TsxB | Uniprot ID | U9Y4R8 |
Locus tag | JR341_RS02575 | Protein ID | WP_000151456.1 |
Coordinates | 7304..7546 (+) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JR341_RS02535 | 2628..2789 | + | 162 | WP_001366886.1 | type I toxin-antitoxin system Hok family toxin | - |
JR341_RS02540 | 2939..3535 | + | 597 | WP_000125165.1 | hypothetical protein | - |
JR341_RS02545 | 3553..3837 | - | 285 | WP_001162371.1 | hypothetical protein | - |
JR341_RS02550 | 3911..4576 | - | 666 | WP_000532149.1 | P-loop NTPase | - |
JR341_RS02555 | 5165..5494 | + | 330 | WP_001542022.1 | hypothetical protein | - |
JR341_RS02560 | 5895..6410 | + | 516 | WP_001025393.1 | J domain-containing protein | - |
JR341_RS02565 | 6514..7056 | + | 543 | WP_001083904.1 | hypothetical protein | - |
JR341_RS02570 | 7053..7307 | + | 255 | WP_001230709.1 | hypothetical protein | Toxin |
JR341_RS02575 | 7304..7546 | + | 243 | WP_000151456.1 | hypothetical protein | Antitoxin |
JR341_RS02580 | 8117..8410 | + | 294 | WP_000673428.1 | hypothetical protein | - |
JR341_RS02585 | 8899..9147 | + | 249 | WP_000513532.1 | type II toxin-antitoxin system HicA family toxin | - |
JR341_RS02590 | 9144..9491 | + | 348 | WP_000681609.1 | type II toxin-antitoxin system HicB family antitoxin | - |
JR341_RS02595 | 9579..9761 | - | 183 | WP_001428470.1 | hypothetical protein | - |
JR341_RS02600 | 10263..10562 | + | 300 | WP_034169410.1 | type II toxin-antitoxin system HicB family antitoxin | - |
JR341_RS02605 | 10822..11148 | - | 327 | WP_000206697.1 | hypothetical protein | - |
JR341_RS02610 | 11150..11590 | - | 441 | WP_023223352.1 | hypothetical protein | - |
JR341_RS02615 | 11610..12317 | - | 708 | WP_000108794.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | mcr-1.1 | - | 1..61726 | 61726 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 9942.47 Da Isoelectric Point: 10.1206
>T191653 WP_001230709.1 NZ_CP069705:7053-7307 [Escherichia coli]
MRKNKGRLTYYLEVIDKKYHFVKKISSYSKEFTDGKTKRTKRTLSELVFNESEVEAIDFTKNGLRPVDKNILLTMVKEYK
ESDA
MRKNKGRLTYYLEVIDKKYHFVKKISSYSKEFTDGKTKRTKRTLSELVFNESEVEAIDFTKNGLRPVDKNILLTMVKEYK
ESDA
Download Length: 255 bp
>T191653 NZ_CP091875:c2027016-2026864 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9136.45 Da Isoelectric Point: 7.2775
>AT191653 WP_000151456.1 NZ_CP069705:7304-7546 [Escherichia coli]
MTIENTPENIKKLRKKIGLTQTECGEIFGVGLSTWQKKEAKTHNQLNLSKGEFEYLLLLAGEHPEYVLHKKAESRSPEEP
MTIENTPENIKKLRKKIGLTQTECGEIFGVGLSTWQKKEAKTHNQLNLSKGEFEYLLLLAGEHPEYVLHKKAESRSPEEP
Download Length: 243 bp
>AT191653 NZ_CP091875:c2027640-2027041 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACTGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATATTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTTGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
CGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACTGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATATTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTTGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
CGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3G9H8F0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3G9GNF5 |