191647

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2017..2552 Replicon plasmid pECY44-2
Accession NZ_CP069703
Organism Escherichia coli strain ECY44

Toxin (Protein)


Gene name relE Uniprot ID T1PX77
Locus tag JR341_RS01280 Protein ID WP_001523468.1
Coordinates 2265..2552 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T1PXV2
Locus tag JR341_RS01275 Protein ID WP_001139206.1
Coordinates 2017..2268 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR341_RS01265 46..1068 + 1023 WP_072645566.1 replication initiation protein -
JR341_RS01270 1763..1930 + 168 WP_072645565.1 hypothetical protein -
JR341_RS01275 2017..2268 + 252 WP_001139206.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JR341_RS01280 2265..2552 + 288 WP_001523468.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JR341_RS01285 2562..3107 + 546 WP_170852536.1 hypothetical protein -
JR341_RS01290 3565..4533 - 969 WP_000654804.1 IS5-like element IS903B family transposase -
JR341_RS01295 4562..4876 - 315 Protein_6 transposase -
JR341_RS01300 4941..5645 + 705 WP_204088838.1 IS6 family transposase -
JR341_RS01305 5703..5909 + 207 WP_063151275.1 hypothetical protein -
JR341_RS01310 6055..6363 - 309 Protein_9 IS5/IS1182 family transposase -
JR341_RS01315 6705..7532 + 828 WP_012637488.1 phosphonate ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..135712 135712


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11142.18 Da        Isoelectric Point: 10.6741

>T191647 WP_001523468.1 NZ_CP069703:2265-2552 [Escherichia coli]
MTYTVKFRDDALREWLRLDKAIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSHVYNLASERMR

Download         Length: 288 bp

>T191647 NZ_CP091872:2096817-2096909 [Bacillus sp. Man122]
ATGTCAACATTCCAGGCATTAATGCTAATGCTTGCAATCGGGTCGTTTATAATCGCCCTATTGACGTATATAGAAAAAAT
AGACCTCCCTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9171.39 Da        Isoelectric Point: 4.0927

>AT191647 WP_001139206.1 NZ_CP069703:2017-2268 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHDVDLD
SYL

Download         Length: 252 bp

>AT191647 NZ_CP091872:c2097063-2096890 [Bacillus sp. Man122]
TTACAATACATTACAGTGCATTTCTTTAATGAGAAATGCATAAAATAAAAAAGACCGAGGTGCTACCAACACCCCGGCTC
TGTACAAAAAGTTGCCCATCAAAGGGCTTGCTCGATGTGGTTCTAGGTAGGCCTATCCCTTCAGGTTCTGAGGCTCAAGG
GAGGTCTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T1PX77

Antitoxin

Source ID Structure
AlphaFold DB T1PXV2

References